Peri-operative fever and LVAD: SIRS or impaired right ventricular strain?

IF 2.2 3区医学 Q3 ENGINEERING, BIOMEDICAL Artificial organs Pub Date : 2024-06-18 DOI:10.1111/aor.14803

Stefanie Marek-Iannucci, Riley Wildemann, Yevgeniy Brailovsky, Samuel Dyer, Maria T. Gamero, Rene J. Alvarez, Eduardo Rame, Howard T. Massey, Vakhtang Tchantchaleishvili, Brandi Thoma, Indranee N. Rajapreyar

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Abstract

Background

An inflammatory milieu after left ventricular assist device (LVAD) implantation is associated with multi-organ dysfunction and pre-operative heightened inflammatory state is associated with right ventricular failure after LVAD implantation.

Methods

We performed a retrospective analysis of 30 LVAD patients in our institution within the last 2 years for the development of fever and compared them to 30 non-LVAD open-heart surgery patients.

Results

Our results suggest that patients undergoing LVAD implantation are more likely to develop fever in the immediate post-operative period compared to other open-heart surgeries. This is independent of pharmacological treatment, age, or ethnical background. Females and obese patients were more likely to develop fever.

Conclusion

Patients with right ventricular dysfunction, as demonstrated by elevated central venous pressure (CVP), had the strongest correlation with fever development. These results pose the question if there is a systemic inflammatory response-like phenomenon driven by increased right ventricular dysfunction.

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围手术期发热与 LVAD：SIRS 还是右心室负荷受损？

背景：左心室辅助装置（LVAD）植入术后的炎症环境与多器官功能障碍有关，术前炎症加重与LVAD植入术后右心室衰竭有关：我们对本机构过去两年中30例LVAD患者的发热情况进行了回顾性分析，并与30例非LVAD开胸手术患者进行了比较：结果：我们的研究结果表明，与其他开胸手术相比，接受 LVAD 植入术的患者在术后初期更容易发烧。这与药物治疗、年龄或种族背景无关。女性和肥胖患者更容易发烧：结论：中心静脉压（CVP）升高显示右心室功能障碍的患者与发烧的关系最为密切。这些结果提出了一个问题：右心室功能不全是否会导致类似全身炎症反应的现象？

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Artificial organs 工程技术-工程：生物医学

CiteScore

4.30

自引率

12.50%

发文量

303

审稿时长

4-8 weeks

期刊介绍： Artificial Organs is the official peer reviewed journal of The International Federation for Artificial Organs (Members of the Federation are: The American Society for Artificial Internal Organs, The European Society for Artificial Organs, and The Japanese Society for Artificial Organs), The International Faculty for Artificial Organs, the International Society for Rotary Blood Pumps, The International Society for Pediatric Mechanical Cardiopulmonary Support, and the Vienna International Workshop on Functional Electrical Stimulation. Artificial Organs publishes original research articles dealing with developments in artificial organs applications and treatment modalities and their clinical applications worldwide. Membership in the Societies listed above is not a prerequisite for publication. Articles are published without charge to the author except for color figures and excess page charges as noted.

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