Maternal periconceptional exposure to drinking water disinfection by-products and neural tube defects in offspring

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY Birth Defects Research Pub Date : 2024-06-18 DOI:10.1002/bdr2.2370

V. Kancherla, A. Rhoads, K. M. Conway, J. Suhl, P. H. Langlois, A. T. Hoyt, G. M. Shaw, S. P. Evans, C. A. Moore, T. J. Luben, A. Michalski, M. L. Feldkamp, P. A. Romitti, the National Birth Defects Prevention Study

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Abstract

Background

Associations between maternal periconceptional exposure to disinfection by-products (DBPs) in drinking water and neural tube defects (NTDs) in offspring are inconclusive, limited in part by exposure misclassification.

Methods

Maternal interview reports of drinking water sources and consumption from the National Birth Defects Prevention Study were linked with DBP concentrations in public water system monitoring data for case children with an NTD and control children delivered during 2000–2005. DBPs analyzed were total trihalomethanes, the five most common haloacetic acids combined, and individual species. Associations were estimated for all NTDs combined and selected subtypes (spina bifida, anencephaly) with maternal periconceptional exposure to DBPs in public water systems and with average daily periconceptional ingestion of DBPs accounting for individual-level consumption and filtration information. Mixed effects logistic regression models with maternal race/ethnicity and educational attainment at delivery as fixed effects and study site as a random intercept were applied.

Results

Overall, 111 case and 649 control children were eligible for analyses. Adjusted odds ratios for maternal exposure to DBPs in public water systems ranged from 0.8–1.5 for all NTDs combined, 0.6–2.0 for spina bifida, and 0.7–1.9 for anencephaly; respective ranges for average daily maternal ingestion of DBPs were 0.7–1.1, 0.5–1.5, and 0.6–1.8. Several positive estimates (≥1.2) were observed, but all confidence intervals included the null.

Conclusions

Using community- and individual-level data from a large, US, population-based, case–control study, we observed statistically nonsignificant associations between maternal periconceptional exposure to total and individual DBP species in drinking water and NTDs and subtypes.

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母亲围孕期接触饮用水消毒副产品与后代神经管缺陷。

背景：母体围孕期暴露于饮用水中的消毒副产物（DBPs）与后代神经管缺陷（NTDs）之间的关系尚无定论，部分原因在于暴露的错误分类：方法：将 "全国出生缺陷预防研究"（National Birth Defects Prevention Study）中关于饮用水来源和消耗量的产妇访谈报告与公共供水系统监测数据中的 DBP 浓度联系起来，这些数据针对的是 2000-2005 年间出生的 NTD 病例患儿和对照组患儿。分析的 DBP 包括总三卤甲烷、五种最常见卤乙酸的总和以及单个物种。我们估算了所有 NTDs 和选定亚型（脊柱裂、无脑畸形）与母亲围孕期暴露于公共供水系统中的 DBPs 以及围孕期日均摄入 DBPs（考虑到个体水平的消耗量和过滤信息）的相关性。混合效应逻辑回归模型以产妇的种族/族裔和分娩时的教育程度为固定效应，研究地点为随机截距：共有 111 名病例儿童和 649 名对照组儿童符合分析条件。产妇暴露于公共供水系统中的 DBPs 的调整后几率比为 0.8-1.5（所有 NTDs 的总和）、0.6-2.0（脊柱裂）和 0.7-1.9（无脑畸形）；产妇日均摄入 DBPs 的范围分别为 0.7-1.1、0.5-1.5 和 0.6-1.8。观察到几个正的估计值（≥1.2），但所有置信区间都包括空值：结论：利用一项大型的、基于美国人口的病例对照研究中的社区和个体水平数据，我们观察到母亲围孕期暴露于饮用水中的总DBP和单个DBP种类与NTD和亚型之间存在统计学意义上的非显著关联。

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.