Low-dose aspirin, maternal cardiometabolic health, and offspring respiratory health 9 to 14 years after delivery: Findings from the EAGeR Follow-up Study.

IF 2.7 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Paediatric and perinatal epidemiology Pub Date : 2024-09-01 Epub Date: 2024-06-17 DOI:10.1111/ppe.13097
May Shaaban, Zachary D Shepelak, Joseph B Stanford, Robert M Silver, Sunni L Mumford, Enrique F Schisterman, Stefanie N Hinkle, Flory L Nkoy, Lauren Theilen, Jessica Page, Jessica G Woo, Benjamin H Brown, Michael W Varner, Karen C Schliep
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Abstract

Background: Accumulating evidence shows that peri-conceptional and in-utero exposures have lifetime health impacts for mothers and their offspring.

Objectives: We conducted a Follow-Up Study of the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial with two objectives. First, we determined if women who enrolled at the Utah site (N = 1001) of the EAGeR trial (2007-2011, N = 1228) could successfully be contacted and agree to complete an online questionnaire on their reproductive, cardio-metabolic, and offspring respiratory health 9-14 years after original enrollment. Second, we evaluated if maternal exposure to low-dose aspirin (LDA) during pregnancy was associated with maternal cardio-metabolic health and offspring respiratory health.

Methods: The original EAGeR study population included women, 18-40 years of age, who had 1-2 prior pregnancy losses, and who were trying to become pregnant. At follow-up (2020-2021), participants from the Utah cohort completed a 13-item online questionnaire on reproductive and cardio-metabolic health, and those who had a live birth during EAGeR additionally completed a 7-item questionnaire on the index child's respiratory health. Primary maternal outcomes included hypertension and hypercholesterolemia; primary offspring outcomes included wheezing and asthma.

Results: Sixty-eight percent (n = 678) of participants enrolled in the follow-up study, with 10% and 15% reporting maternal hypertension and hypercholesterolemia, respectively; and 18% and 10% reporting offspring wheezing and asthma. We found no association between maternal LDA exposure and hypertension (risk difference [RD] -0.001, 95% confidence interval [CI] -0.05, 0.04) or hypercholesterolemia (RD -0.01, 95% CI -0.06, 0.05) at 9-14 years follow-up. Maternal LDA exposure was not associated with offspring wheezing (RD -0.002, 95% CI -0.08, 0.08) or asthma (RD 0.13, 95% CI 0.11, 0.37) at follow-up. Findings remained robust after considering potential confounding and selection bias.

Conclusions: We observed no association between LDA exposure during pregnancy and maternal cardiometabolic or offspring respiratory health.

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低剂量阿司匹林、产妇心脏代谢健康以及产后 9 至 14 年后代的呼吸系统健康:EAGeR随访研究的结果。
背景:越来越多的证据表明,围孕期和胎儿期暴露会对母亲及其后代的终生健康产生影响:我们开展了一项 "阿司匹林对妊娠和生殖影响的随访研究"(EAGeR)试验,目的有两个。首先,我们确定是否能成功联系到在犹他州 EAGeR 试验点注册的妇女(N = 1001)(2007-2011 年,N = 1228),并让她们同意在最初注册 9-14 年后完成一份关于其生殖、心血管代谢和后代呼吸系统健康的在线问卷。其次,我们评估了母亲在怀孕期间接触低剂量阿司匹林(LDA)是否与母亲的心血管代谢健康和后代的呼吸系统健康有关:最初的 EAGeR 研究对象包括年龄在 18-40 岁之间、曾有过 1-2 次妊娠失败经历且正在尝试怀孕的女性。在随访期间(2020-2021 年),犹他州队列的参与者填写了一份包含 13 个项目的关于生殖健康和心血管代谢健康的在线问卷,在 EAGeR 期间活产的参与者还填写了一份包含 7 个项目的关于指标婴儿呼吸健康的问卷。母体的主要结果包括高血压和高胆固醇血症;子代的主要结果包括喘息和哮喘:68%的参与者(n = 678)参加了随访研究,其中分别有 10%和 15%的参与者报告了母体高血压和高胆固醇血症;分别有 18%和 10%的参与者报告了子代喘息和哮喘。我们发现,在9-14年的随访中,母体LDA暴露与高血压(风险差[RD] -0.001,95%置信区间[CI] -0.05,0.04)或高胆固醇血症(RD -0.01,95%置信区间[CI] -0.06,0.05)之间没有关联。随访期间,母体LDA暴露与后代喘息(RD -0.002,95% CI -0.08,0.08)或哮喘(RD 0.13,95% CI 0.11,0.37)无关。在考虑了潜在的混杂因素和选择偏差后,研究结果依然可靠:我们没有观察到孕期LDA暴露与母体心脏代谢或后代呼吸系统健康之间的关系。
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来源期刊
CiteScore
5.40
自引率
7.10%
发文量
84
审稿时长
1 months
期刊介绍: Paediatric and Perinatal Epidemiology crosses the boundaries between the epidemiologist and the paediatrician, obstetrician or specialist in child health, ensuring that important paediatric and perinatal studies reach those clinicians for whom the results are especially relevant. In addition to original research articles, the Journal also includes commentaries, book reviews and annotations.
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