The association between integrin β4 overexpression and lymphovascular invasion in papillary thyroid cancer.

Endokrynologia Polska Pub Date : 2024-01-01 Epub Date: 2024-06-18 DOI:10.5603/ep.99050
Busra Tunc Topuz, Sibel Guldiken, Ebru Tastekin, Canberk Topuz, Mehmet Celik, Buket Yılmaz Bulbul, Burak Andac, Ali Cem Yekdes
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Abstract

Introduction: Lymphovascular invasion is an independent prognostic marker in papillary thyroid carcinomas. In addition, integrin β4 is associated with advanced progression and metastasis in many malignancies. We aimed to investigate the relationship between integrin β4 and lymphovascular invasion in papillary thyroid carcinoma.

Material and methods: 73 patients with papillary thyroid cancer (48 patients with lymphovascular invasion and 25 patients without) were included in our study. The immunohistochemical staining score for integrin b4 was evaluated according to the percentage and intensity of staining. The staining intensity was scored as 0 (no staining), 1 (weak staining - light yellow), 2 (medium staining - yellow-brown), and 3 (strong staining - brown). The staining was scored by multiplying the percentage and intensity of staining.

Results: The mean percentage of integrin b4 staining was 63.54 ± 22.26% in the group with lymphovascular invasion and 10.2 ± 22.48% in the group without lymphovascular invasion (p < 0.001). When evaluated in terms of staining score, it was found to be 107.08 ± 45.29 in the group with lymphovascular invasion and 16.2 ± 40.03 in the group without lymphovascular invasion (p < 0.001). There was a linear relationship between the percentage of integrin β4 and the staining scores (r² = 0.881; p < 0.001). In the by receiver-operating characteristic (ROC) curve analysis for the cut-off value of the percentage of integrin b4 staining, the area under the curve was found to be 0.916. The cut-off value for the percentage of integrin b4 was found to be 35 (sensitivity 91.7% and specificity 88%) (odds 80.66%).

Conclusions: A significant relationship was found between integrin b4 expression and lymphovascular invasion in papillary thyroid carcinomas. Integrin b4 expression level can be used as a marker to predict the presence of lymphovascular invasion in papillary thyroid carcinomas, especially in large tumours where it may not be possible to sample the entire tumour.

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甲状腺乳头状癌中整合素β4过表达与淋巴管侵犯之间的关系
简介:淋巴管侵犯是甲状腺乳头状癌的独立预后标志:淋巴管侵犯是甲状腺乳头状癌的一个独立预后标志。此外,整合素β4与许多恶性肿瘤的晚期进展和转移有关。我们旨在研究整合素β4与甲状腺乳头状癌淋巴管侵犯之间的关系。根据整合素 b4 的染色百分比和染色强度评估整合素 b4 的免疫组化染色评分。染色强度分为 0(无染色)、1(弱染色-浅黄色)、2(中度染色-黄褐色)和 3(强染色-褐色)。染色的评分标准是染色的百分比和染色的强度相乘:有淋巴管侵犯组整合素 b4 染色的平均百分比为(63.54 ± 22.26)%,无淋巴管侵犯组整合素 b4 染色的平均百分比为(10.2 ± 22.48)%(P < 0.001)。根据染色评分进行评估后发现,有淋巴管侵犯组为 107.08 ± 45.29,无淋巴管侵犯组为 16.2 ± 40.03(P < 0.001)。整合素β4的百分比与染色评分之间存在线性关系(r² = 0.881;p < 0.001)。通过对整合素 b4 染色百分比的临界值进行接收器操作特征(ROC)曲线分析,发现曲线下面积为 0.916。整合素 b4 百分比的临界值为 35(敏感性 91.7%,特异性 88%)(几率 80.66%):结论:研究发现整合素b4的表达与甲状腺乳头状癌的淋巴管侵犯有重要关系。整合素b4的表达水平可作为预测甲状腺乳头状癌中是否存在淋巴管侵犯的标志物,尤其是在无法对整个肿瘤进行取样的大型肿瘤中。
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