Understanding the influence of cytokines in intrauterine hepatitis B transmission: A cross-sectional study in China

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine Pub Date : 2024-06-18 DOI:10.1016/j.cyto.2024.156670

Xiaojie Yuan , Yuzhang Shao , Rui Huang , Samuel Seery , Hairong Wang , Ni Hu , Leji Wen , Xin Lin , Lei Zhang

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Abstract

Cytokines may related to intrauterine Hepatitis B virus (HBV) transmission. 205 HBsAg(+) pregnant cases and 74 HBsAg(−) women were included. Neonatal blood samples were taken within 24 h of delivery and before HBV vaccinations. Serological HBV biomarkers and cytokines were detected. 21.9 % of the newborns from HBsAg(+) women were intrauterinally transmitted, including 7.3 % with dominant transmission (DBT) and 14.6 % occult transmission (OBT). HBV DNA load (odd ratio [OR], 1.44; 95 % confidence interval [CI], 1.05–1.98), interferon-γ (IFN-γ) (OR, 1.01; 95 %CI, 1.00–1.02) and toll-like receptor 9 (TLR9) (OR, 1.27; 95 %CI, 1.06–1.52) positively correlated with DBT. Only IFN-γ (OR, 1.01; 95 %CI, 1.00–1.01) positively associated with OBT. According to the generated restricted cubic spline, TLR9 was positively correlates with rise of DBT in a log-shape. It may be possible to develop a nomogram which intercalates these factors to predict intrauterine HBV transmissions. Further research should consider immune processes involved in chorioamnionitis.

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了解细胞因子对宫内乙肝传播的影响：中国横断面研究

细胞因子可能与宫内乙型肝炎病毒（HBV）传播有关。研究对象包括 205 名 HBsAg（+）孕妇和 74 名 HBsAg（-）孕妇。新生儿血样在分娩后 24 小时内和接种 HBV 疫苗前采集。检测了血清学 HBV 生物标志物和细胞因子。21.9% 的 HBsAg（+）女性新生儿经宫内传播，其中 7.3% 为显性传播（DBT），14.6% 为隐性传播（OBT）。HBV DNA 负荷（奇数比 [OR]，1.44；95% 置信区间 [CI]，1.05-1.98）、干扰素-γ (IFN-γ)（OR，1.01；95%CI，1.00-1.02）和收费样受体 9 (TLR9)（OR，1.27；95%CI，1.06-1.52）与 DBT 呈正相关。只有 IFN-γ（OR，1.01；95 %CI，1.00-1.01）与 OBT 呈正相关。根据生成的限制性三次样条，TLR9 与 DBT 的上升呈对数正相关。也许有可能建立一个包含这些因素的提名图来预测宫内 HBV 传播。进一步的研究应考虑绒毛膜羊膜炎所涉及的免疫过程。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.