Natural killer cell-mediated innate microvascular rejection

IF 28.6 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Nephrology Pub Date : 2024-06-19 DOI:10.1038/s41581-024-00862-w
Olivier Thaunat
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Abstract

Graft rejection is traditionally attributed to adaptive immune cells that recognize donor-specific alloantigens, with innate immunity having a secondary role. The finding that recipient natural killer cells are activated by the inability of graft endothelial cells to provide HLA-I-mediated inhibitory signals challenges this dogma and introduces the concept of innate rejection.

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自然杀伤细胞介导的先天性微血管排斥反应
传统上,移植物排斥反应归因于识别供体特异性异体抗原的适应性免疫细胞,先天性免疫起次要作用。受体自然杀伤细胞因移植物内皮细胞无法提供 HLA-I 介导的抑制信号而被激活,这一发现挑战了这一教条,并引入了先天性排斥反应的概念。
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来源期刊
Nature Reviews Nephrology
Nature Reviews Nephrology 医学-泌尿学与肾脏学
CiteScore
39.00
自引率
1.20%
发文量
127
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.
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