Palladium(II)-Catalyzed Norbornene-Mediated Selective meta-C–H Silylation for the Synthesis of Arylsilanes from Primary Benzamides

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2024-06-20 DOI:10.1021/acs.orglett.4c01841

Wenguang Li*, Shukui Shi, Man Cao, Wenchao Gao, Xu Zhang, Wentao Li, Yongqi Yu* and Ting Li*,

引用次数: 0

Abstract

A palladium(II)-catalyzed norbornene-mediated remote selective meta-C–H silylation of primary benzamides was developed for the synthesis of arylsilanes. Such a conversion provides access to a range of arylsilanes with exclusive selectivity using norbornene (NBE) as the meta-C–H activator. The amide directing group can be detached simultaneously through C–C bond cleavage or undergo a dehydration reaction pathway to form nitriles.

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钯(II)催化的降冰片烯选择性元-C-H 硅烷化作用，用于从初级苯甲酰胺合成芳基硅烷。

为合成芳基硅烷，开发了一种钯（II）催化的降冰片烯介导的伯氨基苯甲酰胺远程选择性元-C-H 硅烷化反应。利用降冰片烯（NBE）作为元-C-H 激活剂，这种转化可以获得一系列具有独特选择性的芳基硅烷。酰胺指导基团可同时通过 C-C 键裂解脱离，或通过脱水反应途径形成腈。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.