Global, interhemispheric and intrahemispheric functional connection patterns in male adults with alcohol use disorder

IF 3.1 3区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Addiction Biology Pub Date : 2024-06-20 DOI:10.1111/adb.13398
Yarui Wei, Weijian Wang, Yimeng Kang, Xiaoyu Niu, Zanxia Zhang, Shujian Li, Shaoqiang Han, Jingliang Cheng, Yong Zhang
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Abstract

A growing body of evidence indicates the existence of abnormal local and long-range functional connection patterns in patients with alcohol use disorder (AUD). However, it has yet to be established whether AUD is associated with abnormal interhemispheric and intrahemispheric functional connection patterns. In the present study, we analysed resting-state functional magnetic resonance imaging data from 55 individuals with AUD and 32 healthy nonalcohol users. For each subject, whole-brain functional connectivity density (FCD) was decomposed into ipsilateral and contralateral parts. Correlation analysis was performed between abnormal FCD and a range of clinical measurements in the AUD group. Compared with healthy controls, the AUD group exhibited a reduced global FCD in the anterior and middle cingulate gyri, prefrontal cortex and thalamus, along with an enhanced global FCD in the temporal, parietal and occipital cortices. Abnormal interhemispheric and intrahemispheric FCD patterns were also detected in the AUD group. Furthermore, abnormal global, contralateral and ipsilateral FCD data were correlated with the mean amount of pure alcohol and the severity of alcohol addiction in the AUD group. Collectively, our findings indicate that global, interhemispheric and intrahemispheric FCD may represent a robust method to detect abnormal functional connection patterns in AUD; this may help us to identify the neural substrates and therapeutic targets of AUD.

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酒精使用障碍男性成人的大脑半球、半球间和半球内功能连接模式。
越来越多的证据表明,酒精使用障碍(AUD)患者存在异常的局部和长程功能连接模式。然而,酒精中毒性精神障碍是否与大脑半球间和半球内的异常功能连接模式有关,目前尚无定论。在本研究中,我们分析了 55 名 AUD 患者和 32 名健康非酒精使用者的静息状态功能磁共振成像数据。我们将每个受试者的全脑功能连接密度(FCD)分解为同侧和对侧两个部分。在 AUD 组中,异常 FCD 与一系列临床测量结果之间进行了相关性分析。与健康对照组相比,AUD 组在扣带回前部和中部、前额叶皮层和丘脑中的全局 FCD 减少,而在颞叶、顶叶和枕叶皮层中的全局 FCD 增加。在 AUD 组中还发现了异常的半球间和半球内 FCD 模式。此外,全球、对侧和同侧 FCD 数据异常与 AUD 组的平均纯酒精量和酒精成瘾严重程度相关。总之,我们的研究结果表明,全局、半球间和半球内FCD可能是检测AUD异常功能连接模式的可靠方法;这可能有助于我们确定AUD的神经基质和治疗目标。
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来源期刊
Addiction Biology
Addiction Biology 生物-生化与分子生物学
CiteScore
8.10
自引率
2.90%
发文量
118
审稿时长
6-12 weeks
期刊介绍: Addiction Biology is focused on neuroscience contributions and it aims to advance our understanding of the action of drugs of abuse and addictive processes. Papers are accepted in both animal experimentation or clinical research. The content is geared towards behavioral, molecular, genetic, biochemical, neuro-biological and pharmacology aspects of these fields. Addiction Biology includes peer-reviewed original research reports and reviews. Addiction Biology is published on behalf of the Society for the Study of Addiction to Alcohol and other Drugs (SSA). Members of the Society for the Study of Addiction receive the Journal as part of their annual membership subscription.
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