The association of T102C (rs6313) polymorphism in the 5-HT2A receptor gene with temporomandibular disorders and anxiety in a group of Turkish population.

IF 2 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Cranio-The Journal of Craniomandibular & Sleep Practice Pub Date : 2024-06-20 DOI:10.1080/08869634.2024.2369729

Ömer Ekici, Evrim Suna Arıkan Söylemez

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Abstract

Objective: To investigate the relationship between T102C (rs6313) polymorphism in the 5-hydroxytryptamine receptor-2A (5HTR2A) gene and temporomandibular disorder (TMD) and anxiety.

Methods: This observational case-control study included 80 patients and 70 healthy controls. TMD was diagnosed using the criteria for TMD (DC/TMD). Anxiety was assessed with the Beck anxiety scale. A genotyping study of HTRR2A T102C (rs6313) gene polymorphism was performed from genomic DNA isolated from blood.

Results: The TMD group had higher anxiety scores than the control group (p < .05). The TMD group was similar to the control group regarding genotype and allele frequencies. However, the polymorphic CC genotype was more common in those with high anxiety (p < .05).

Conclusion: There was no clear evidence of an association between TMD and the T102C polymorphism in HTR2A and TMD. However, anxiety is closely related to the T102C polymorphism in HTR2A.

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土耳其人群中 5-HT2A 受体基因中的 T102C（rs6313）多态性与颞下颌关节紊乱和焦虑的关系。

目的研究5-羟色胺受体-2A（5HTR2A）基因中T102C（rs6313）多态性与颞下颌关节紊乱（TMD）和焦虑之间的关系：这项观察性病例对照研究包括 80 名患者和 70 名健康对照者。TMD根据TMD（DC/TMD）标准进行诊断。焦虑采用贝克焦虑量表进行评估。从血液中分离的基因组 DNA 对 HTRR2A T102C (rs6313) 基因多态性进行了基因分型研究：结果：TMD 组的焦虑评分高于对照组（p p 结论：TMD 组的焦虑评分高于对照组（p p 结论：TMD 组的焦虑评分高于对照组（p p）：没有明确证据表明 TMD 与 HTR2A 的 T102C 多态性和 TMD 之间存在关联。然而，焦虑与 HTR2A 的 T102C 多态性密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cranio-The Journal of Craniomandibular & Sleep Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.50

自引率

12.50%

发文量

审稿时长

>12 weeks

期刊介绍： CRANIO: The Journal of Craniomandibular & Sleep Practice is the oldest and largest journal in the world devoted to temporomandibular disorders, and now also includes articles on all aspects of sleep medicine. The Journal is multidisciplinary in its scope, with editorial board members from all areas of medicine and dentistry, including general dentists, oral surgeons, orthopaedists, radiologists, chiropractors, professors and behavioural scientists, physical therapists, acupuncturists, osteopathic and ear, nose and throat physicians. CRANIO publishes commendable works from outstanding researchers and clinicians in their respective fields. The multidisciplinary format allows individuals practicing with a TMD emphasis to stay abreast of related disciplines, as each issue presents multiple topics from overlapping areas of interest. CRANIO''s current readership (thousands) is comprised primarily of dentists; however, many physicians, physical therapists, chiropractors, osteopathic physicians and other related specialists subscribe and contribute to the Journal.