Peyer’s Patch: Possible target for modulating the Gut-Brain-Axis through microbiota

IF 3.7 4区 医学 Q2 CELL BIOLOGY Cellular immunology Pub Date : 2024-06-18 DOI:10.1016/j.cellimm.2024.104844
Reza Asgari , Mohammad Amin Bazzazan , Ashkan Karimi Jirandehi , Salar Yousefzadeh , Masood Alaei , Sanaz Keshavarz Shahbaz
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Abstract

The gastrointestinal (GI) tract and the brain form bidirectional nervous, immune, and endocrine communications known as the gut-brain axis. Several factors can affect this axis; among them, various studies have focused on the microbiota and imply that alterations in microbiota combinations can influence both the brain and GI. Also, many studies have shown that the immune system has a vital role in varying gut microbiota combinations. In the current paper, we will review the multidirectional effects of gut microbiota, immune system, and nervous system on each other. Specifically, this review mainly focuses on the impact of Peyer’s patches as a critical component of the gut immune system on the gut-brain axis through affecting the gut’s microbial composition. In this way, some factors were discussed as proposed elements of missing gaps in this field.

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佩尔氏斑:通过微生物群调节肠-脑-轴的可能目标
胃肠道(GI)和大脑形成双向的神经、免疫和内分泌沟通,被称为肠脑轴。有几种因素会影响这一轴线;其中,各种研究重点关注微生物群,并暗示微生物群组合的改变会影响大脑和胃肠道。此外,许多研究还表明,免疫系统在不同的肠道微生物群组合中起着至关重要的作用。在本文中,我们将综述肠道微生物群、免疫系统和神经系统之间的多向影响。具体来说,本综述主要关注佩耶氏斑块作为肠道免疫系统的重要组成部分,通过影响肠道微生物组成对肠道-大脑轴的影响。通过这种方式,讨论了一些因素作为该领域缺失缺口的拟议要素。
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来源期刊
Cellular immunology
Cellular immunology 生物-免疫学
CiteScore
8.20
自引率
2.30%
发文量
102
审稿时长
30 days
期刊介绍: Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.
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