Spatial metabolomics in tissue injury and regeneration

IF 3.7 2区生物学 Q2 CELL BIOLOGY Current Opinion in Genetics & Development Pub Date : 2024-06-19 DOI:10.1016/j.gde.2024.102223

Rosalie GJ Rietjens , Gangqi Wang , Bernard M van den Berg, Ton J Rabelink

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Abstract

Tissue homeostasis is intricately linked to cellular metabolism and metabolite exchange within the tissue microenvironment. The orchestration of adaptive cellular responses during injury and repair depends critically upon metabolic adaptation. This adaptation, in turn, shapes cell fate decisions required for the restoration of tissue homeostasis. Understanding the nuances of metabolic processes within the tissue context and comprehending the intricate communication between cells is therefore imperative for unraveling the complexity of tissue homeostasis and the processes of injury and repair. In this review, we focus on mass spectrometry imaging as an advanced platform with the potential to provide such comprehensive insights into the metabolic instruction governing tissue function. Recent advances in this technology allow to decipher the intricate metabolic networks that determine cellular behavior in the context of tissue resilience, injury, and repair. These insights not only advance our fundamental understanding of tissue biology but also hold implications for therapeutic interventions by targeting metabolic pathways critical for maintaining tissue homeostasis.

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组织损伤和再生中的空间代谢组学

组织稳态与组织微环境中的细胞代谢和代谢物交换密切相关。在损伤和修复过程中，细胞适应性反应的协调在很大程度上取决于新陈代谢的适应性。这种适应反过来又决定了恢复组织稳态所需的细胞命运。因此，了解组织内代谢过程的细微差别以及理解细胞间错综复杂的交流，对于揭示组织稳态的复杂性以及损伤和修复过程至关重要。在这篇综述中，我们将重点介绍质谱成像技术，它是一种先进的平台，有可能提供有关组织功能代谢指令的全面见解。这项技术的最新进展可以破译在组织恢复、损伤和修复过程中决定细胞行为的错综复杂的代谢网络。这些见解不仅增进了我们对组织生物学的基本了解，而且还对针对维持组织稳态的关键代谢途径进行治疗干预产生了影响。

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)

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