The single point insulin sensitivity estimator (SPISE) is associated with bone health in Arab adults.

IF 3.4 3区 医学 Q2 GERIATRICS & GERONTOLOGY Aging Clinical and Experimental Research Pub Date : 2024-06-21 DOI:10.1007/s40520-024-02789-5
Nasser M Al-Daghri, Kaiser Wani, Malak N K Khattak, Abdullah M Alnaami, Yousef Al-Saleh, Shaun Sabico
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Abstract

Background: The Single Point Insulin Sensitivity Estimator (SPISE) index is a surrogate marker for insulin sensitivity. Given the emerging role of bone as an active endocrine organ, its associations with non-invasive measures of extra-skeletal functions such as insulin sensitivity warrant investigation.

Aims: This study aimed to explore the relationship between the SPISE index and Bone Mineral Density (BMD) in an adult population.

Methods: Data from a total of 1270 Arab adults (84% females, mean age 56.7 ± 8.1 years) from the Osteoporosis Registry Database of the Chair for Biomarkers of Chronic Diseases in King Saud University, Riyadh, Saudi Arabia was used in this study. T-scores and SPISE were calculated. Regression models were used to determine associations between SPISE and bone health indices.

Results: The low BMD group (N = 853; T-score <-1.0) had significantly higher SPISE values than those with normal BMD (N = 417; T-score - 1.0 and above) (4.6 ± 1.3 vs. 4.3 ± 1.2, p < 0.001). Multivariate linear regression, adjusted for covariates, confirmed a significant inverse association between SPISE and BMD for all participants (β=-0.22, p < 0.001), as well as both groups [normal BMD (β = -0.10, p = 0.02) and low BMD groups (β = -0.15, p < 0.001)]. SPISE, family history of T2DM, and history of fractures collectively account for 17% of the variances perceived in T-score for all participants (p < 0.001).

Conclusions: A significant inverse association between the SPISE index and BMD was observed in adults, suggesting a link between BMD and extra-skeletal health. Underlying mechanisms need to be investigated prospectively using BMD as secondary outcomes in lifestyle modification programs.

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单点胰岛素敏感性估计值(SPISE)与阿拉伯成年人的骨骼健康有关。
背景:单点胰岛素敏感性估计指数(SPISE)是胰岛素敏感性的替代指标。鉴于骨骼作为一个活跃的内分泌器官的作用正在显现,其与胰岛素敏感性等骨骼外功能的非侵入性测量之间的关系值得研究:本研究使用了沙特阿拉伯利雅得沙特国王大学慢性病生物标志物研究中心骨质疏松症登记数据库中的 1270 名阿拉伯成年人(84% 为女性,平均年龄为 56.7 ± 8.1 岁)的数据。计算了 T 值和 SPISE。使用回归模型确定 SPISE 与骨健康指数之间的关系:结果:低 BMD 组(N = 853;T-score 结论:SPISE 与骨健康指数之间存在显著的反向关系:在成人中观察到 SPISE 指数与 BMD 之间存在明显的反向关系,这表明 BMD 与骨骼外健康之间存在联系。需要将 BMD 作为生活方式调整计划的次要结果,对其基本机制进行前瞻性研究。
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来源期刊
CiteScore
7.90
自引率
5.00%
发文量
283
审稿时长
1 months
期刊介绍: Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.
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