Relation between interleukin-13 and annexin-V levels and carotid intima-media thickness in nephrotic syndrome.

Q3 Medicine Journal of Circulating Biomarkers Pub Date : 2024-06-18 eCollection Date: 2024-01-01 DOI:10.33393/jcb.2024.2689
Asmaa A Elsehmawy, Rasha M Gouda, Fatma Elzhraa A E Diab, Ola I Saleh, Heba M Galal, Mona G Al Anany, Salwa S Abd Elgawad, Marwa M Hassan, Mohamed A M Kamal, Ahmed Y Elamir
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Abstract

Background and aim: The aim of the current study is to assess the relation between carotid intima-media thickness (CIMT) measurements, renal Doppler resistive index (RI) and serum levels of interleukin-13 (IL-13) and annexin-V (An-V) in children with idiopathic nephrotic syndrome (INS).

Materials and methods: The present case-control study was conducted on 60 children with INS and 60 age- and sex-matched healthy children. All participants were subjected to evaluation of serum levels of IL-13 and An-V and ultrasound Doppler measurement of CIMT and renal RI.

Results: Patients expressed significantly higher An-V (5.9 ± 2.6 vs. 2.1 ± 0.8 ng/mL, p<0.001) and IL-13 (19.2 ± 7.6 vs. 3.4 ± 1.4 ng/L) levels when compared with healthy counterparts. Moreover, it was shown that patients had significantly higher CIMT (0.49 ± 0.06 vs. 0.35 ± 0.03, p<0.001) as compared to controls. No significant differences were noted between the studied groups regarding right or left RIs. Correlation analysis identified significant direct correlation between serum An-V levels and albumin/creatinine ratio (ACR) (r = 0.55), cholesterol (r = 0.48), triglycerides (r = 0.36), IL-13 (r = 0.92) and CIMT (r = 0.53). Similar correlations could be found between serum IL-13 levels and CIMT measurements and the corresponding parameters.

Conclusions: The present study suggests an association between higher early atherosclerosis expressed as elevated CIMT measurements in children with INS and elevated serum levels of An-V and IL-13.

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肾病综合征患者白细胞介素-13和附件素-V水平与颈动脉内膜中层厚度之间的关系
背景和目的:本研究旨在评估特发性肾病综合征(INS)患儿颈动脉内膜中层厚度(CIMT)测量值、肾脏多普勒阻力指数(RI)与血清白细胞介素-13(IL-13)和附件素-V(An-V)水平之间的关系:本病例对照研究的对象是 60 名特发性肾病综合征患儿和 60 名年龄和性别匹配的健康儿童。所有参与者均接受了血清 IL-13 和 An-V 水平评估以及 CIMT 和肾 RI 的超声多普勒测量:结果:患者的 An-V 明显更高(5.9 ± 2.6 vs. 2.1 ± 0.8 ng/mL,p):本研究表明,INS患儿早期动脉粥样硬化程度较高(表现为CIMT测量值升高)与血清中An-V和IL-13水平升高之间存在关联。
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来源期刊
Journal of Circulating Biomarkers
Journal of Circulating Biomarkers Medicine-Biochemistry (medical)
CiteScore
3.20
自引率
0.00%
发文量
9
审稿时长
8 weeks
期刊介绍: Journal of Circulating Biomarkers is an international, peer-reviewed, open access scientific journal focusing on all aspects of the rapidly growing field of circulating blood-based biomarkers and diagnostics using circulating protein and lipid markers, circulating tumor cells (CTC), circulating cell-free DNA (cfDNA) and extracellular vesicles, including exosomes, microvesicles, microparticles, ectosomes and apoptotic bodies. The journal publishes high-impact articles that deal with all fields related to circulating biomarkers and diagnostics, ranging from basic science to translational and clinical applications. Papers from a wide variety of disciplines are welcome; interdisciplinary studies are especially suitable for this journal. Included within the scope are a broad array of specialties including (but not limited to) cancer, immunology, neurology, metabolic diseases, cardiovascular medicine, regenerative medicine, nosology, physiology, pathology, technological applications in diagnostics, therapeutics, vaccine, drug delivery, regenerative medicine, drug development and clinical trials. The journal also hosts reviews, perspectives and news on specific topics.
期刊最新文献
A novel liquid biopsy assay for detection of ERBB2 (HER2) amplification in circulating tumor cells (CTCs). Comments to: Relation between interleukin-13 and annexin-V levels and carotid intima-media thickness in nephrotic syndrome. Author's reply to: Comments to: Relation between interleukin-13 and annexin-V levels and carotid intima-media thickness in nephrotic syndrome. Comparative evaluation of serum and gingival crevicular fluid levels of interleukin 21 in periodontally diseased and healthy patients. Relation between interleukin-13 and annexin-V levels and carotid intima-media thickness in nephrotic syndrome.
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