Samuel R Schnittman, Ria Talathi, Moses Q Wilks, Sandeep Hedgire, Michael T Lu, Lindsay T Fourman, David A Alagpulinsa, Sara L Stockman, Kevin S White, Zoey K Wallis, Patrick Autissier, Takara L Stanley, Hang Lee, Michael C Honigberg, Georges El-Fakhri, Kenneth C Williams, Markella V Zanni, Steven K Grinspoon, Mabel Toribio
{"title":"Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV.","authors":"Samuel R Schnittman, Ria Talathi, Moses Q Wilks, Sandeep Hedgire, Michael T Lu, Lindsay T Fourman, David A Alagpulinsa, Sara L Stockman, Kevin S White, Zoey K Wallis, Patrick Autissier, Takara L Stanley, Hang Lee, Michael C Honigberg, Georges El-Fakhri, Kenneth C Williams, Markella V Zanni, Steven K Grinspoon, Mabel Toribio","doi":"10.1097/QAD.0000000000003967","DOIUrl":null,"url":null,"abstract":"<p><p>People with human immunodeficiency virus (HIV, PWH) face an increased risk of cardiovascular disease (CVD) compared to the general population. We previously demonstrated that people with (versus without) HIV have higher macrophage-specific arterial infiltration in relation to systemic monocyte activation. We now show that select T lymphocyte subpopulations (naïve CD4 + , effector memory CD4 + , and central memory CD8 + ) are differentially associated with macrophage-specific arterial infiltration among participants with versus without HIV, with evidence of interaction by HIV status. Our results suggest that among PWH, circulating T lymphocytes associate with macrophage-specific arterial infiltration, of relevance to atherogenesis and CVD risk.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1940-1946"},"PeriodicalIF":3.4000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AIDS","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/QAD.0000000000003967","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
People with human immunodeficiency virus (HIV, PWH) face an increased risk of cardiovascular disease (CVD) compared to the general population. We previously demonstrated that people with (versus without) HIV have higher macrophage-specific arterial infiltration in relation to systemic monocyte activation. We now show that select T lymphocyte subpopulations (naïve CD4 + , effector memory CD4 + , and central memory CD8 + ) are differentially associated with macrophage-specific arterial infiltration among participants with versus without HIV, with evidence of interaction by HIV status. Our results suggest that among PWH, circulating T lymphocytes associate with macrophage-specific arterial infiltration, of relevance to atherogenesis and CVD risk.
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Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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