Activation changes in patients with post-stroke cognitive impairment receiving intermittent theta burst stimulation: A functional near-infrared spectroscopy study.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY NeuroRehabilitation Pub Date : 2024-01-01 DOI:10.3233/NRE-240068

Hong Yu, Beisi Zheng, Youmei Zhang, Minmin Chu, Xinxin Shu, Xiaojun Wang, Hani Wang, Siwei Zhou, Manting Cao, Shilin Wen, Jianer Chen

{"title":"Activation changes in patients with post-stroke cognitive impairment receiving intermittent theta burst stimulation: A functional near-infrared spectroscopy study.","authors":"Hong Yu, Beisi Zheng, Youmei Zhang, Minmin Chu, Xinxin Shu, Xiaojun Wang, Hani Wang, Siwei Zhou, Manting Cao, Shilin Wen, Jianer Chen","doi":"10.3233/NRE-240068","DOIUrl":null,"url":null,"abstract":"Background: Intermittent theta burst stimulation (iTBS) has demonstrated efficacy in patients with cognitive impairment. However, activation patterns and mechanisms of iTBS for post-stroke cognitive impairment (PSCI) remain insufficiently understood.Objective: To investigate the activation patterns and potential benefits of using iTBS in patients with PSCI.Methods: A total of forty-four patients with PSCI were enrolled and divided into an iTBS group (iTBS and cognitive training) or a control group (cognitive training alone). Outcomes were assessed based on the activation in functional near-infrared spectroscopy (fNIRS), as well as Loewenstein Occupational Therapy Cognitive Assessment (LOTCA) and the modified Barthel Index (MBI).Results: Thirty-eight patients completed the interventions and assessments. Increased cortical activation was observed in the iTBS group after the interventions, including the right superior temporal gyrus (STG), left frontopolar cortex (FPC) and left orbitofrontal cortex (OFC). Both groups showed significant improvements in LOTCA and MBI after the interventions (p < 0.05). Furthermore, the iTBS group augmented superior improvement in the total score of MBI and LOTCA compared to the control group, especially in visuomotor organization and thinking operations (p < 0.05).Conclusion: iTBS altered activation patterns and improved cognitive function in patients with PSCI. The activation induced by iTBS may contribute to the improvement of cognitive function.","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"677-690"},"PeriodicalIF":1.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307044/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"NeuroRehabilitation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3233/NRE-240068","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Intermittent theta burst stimulation (iTBS) has demonstrated efficacy in patients with cognitive impairment. However, activation patterns and mechanisms of iTBS for post-stroke cognitive impairment (PSCI) remain insufficiently understood.

Objective: To investigate the activation patterns and potential benefits of using iTBS in patients with PSCI.

Methods: A total of forty-four patients with PSCI were enrolled and divided into an iTBS group (iTBS and cognitive training) or a control group (cognitive training alone). Outcomes were assessed based on the activation in functional near-infrared spectroscopy (fNIRS), as well as Loewenstein Occupational Therapy Cognitive Assessment (LOTCA) and the modified Barthel Index (MBI).

Results: Thirty-eight patients completed the interventions and assessments. Increased cortical activation was observed in the iTBS group after the interventions, including the right superior temporal gyrus (STG), left frontopolar cortex (FPC) and left orbitofrontal cortex (OFC). Both groups showed significant improvements in LOTCA and MBI after the interventions (p < 0.05). Furthermore, the iTBS group augmented superior improvement in the total score of MBI and LOTCA compared to the control group, especially in visuomotor organization and thinking operations (p < 0.05).

Conclusion: iTBS altered activation patterns and improved cognitive function in patients with PSCI. The activation induced by iTBS may contribute to the improvement of cognitive function.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

脑卒中后认知障碍患者接受间歇θ脉冲刺激后的激活变化：功能性近红外光谱研究。

背景：间歇性θ脉冲刺激（iTBS）对认知障碍患者具有疗效。然而，人们对 iTBS 治疗卒中后认知障碍（PSCI）的激活模式和机制仍缺乏足够了解：目的：研究 iTBS 对脑卒中后认知障碍患者的激活模式和潜在益处：共招募了 44 名 PSCI 患者，并将其分为 iTBS 组（iTBS 和认知训练）或对照组（仅认知训练）。结果根据功能性近红外光谱（fNIRS）的激活情况、卢温斯坦职业治疗认知评估（LOTCA）和改良巴特尔指数（MBI）进行评估：38名患者完成了干预和评估。干预后观察到 iTBS 组皮质激活增加，包括右侧颞上回（STG）、左侧额叶皮质（FPC）和左侧眶额皮质（OFC）。干预后，两组患者的 LOTCA 和 MBI 均有明显改善（p 结论：iTBS 改变了 PSCI 患者的激活模式，改善了他们的认知功能。iTBS 诱导的激活可能有助于认知功能的改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

NeuroRehabilitation CLINICAL NEUROLOGY-REHABILITATION

CiteScore

3.20

自引率

0.00%

发文量

178

审稿时长

6-12 weeks

期刊介绍： NeuroRehabilitation, an international, interdisciplinary, peer-reviewed journal, publishes manuscripts focused on scientifically based, practical information relevant to all aspects of neurologic rehabilitation. We publish unsolicited papers detailing original work/research that covers the full life span and range of neurological disabilities including stroke, spinal cord injury, traumatic brain injury, neuromuscular disease and other neurological disorders. We also publish thematically organized issues that focus on specific clinical disorders, types of therapy and age groups. Proposals for thematic issues and suggestions for issue editors are welcomed.