Rho GTPase-activating protein 4 is upregulated in Kidney Renal Clear Cell Carcinoma and associated with poor prognosis and immune infiltration.

IF 2.2 4区医学 Q3 ONCOLOGY Cancer Biomarkers Pub Date : 2024-01-01 DOI:10.3233/CBM-230388

Xuesong Xiao, Xiaofei Lv, Tianyu Lin, Jianqiao Li, Rui Wang, Shaoping Tian, Xinyu Liu, Shiming Liu, Huamao Jiang, Dan Yue, Yong Wang

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Abstract

Background: Kidney Renal Clear Cell Carcinoma (KIRC) is a malignant tumor that seriously threatens human health. Rho GTPase-activating protein 4 (ARHGAP4) plays an important role in the occurrence and development of tumors.

Objective: The purpose of this study was to explore the role of ARHGAP4 in the progression of KIRC and its diagnostic and prognostic value.

Methods: Multiple analytical methods and in vitro cell assays were used to explore the expression of ARHGAP4 and its value in the progression, diagnosis and prognosis of KIRC. The biological function of ARHGAP4 was studied by GO analysis and KEGG pathway analysis, and then the relationship between ARHGAP4 and immune infiltration was analyzed.

Results: The expression of ARHGAP4 was significantly up-regulated in KIRC. We found that the high expression of ARHGAP4 was related to the progression of KIRC and suggested a poor prognosis. Compared with normal tissues, ARHGAP4 had a better diagnostic value in KIRC. The biological function of ARHGAP4 was related to immunity, and its expression was also closely related to tumor immune infiltration and immune checkpoints.

Conclusions: Our study demonstrated that ARHGAP4 may be a biomarker, which is related to the progression, diagnosis and prognosis of KIRC. Its biological functions are related to tumor immune infiltration.

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Rho GTPase-activating protein 4在肾透明细胞癌中上调，与预后不良和免疫浸润有关。

背景：肾透明细胞癌（KIRC肾透明细胞癌（KIRC）是一种严重威胁人类健康的恶性肿瘤。Rho GTPase-activating protein 4 (ARHGAP4) 在肿瘤的发生和发展过程中发挥着重要作用：本研究旨在探讨 ARHGAP4 在 KIRC 进展中的作用及其诊断和预后价值：方法：采用多种分析方法和体外细胞实验探讨ARHGAP4的表达及其在KIRC的进展、诊断和预后中的价值。通过GO分析和KEGG通路分析研究了ARHGAP4的生物学功能，然后分析了ARHGAP4与免疫浸润的关系：结果：ARHGAP4在KIRC中的表达明显上调。我们发现，ARHGAP4的高表达与KIRC的进展有关，预后较差。与正常组织相比，ARHGAP4 在 KIRC 中具有更好的诊断价值。ARHGAP4的生物学功能与免疫有关，其表达也与肿瘤免疫浸润和免疫检查点密切相关：我们的研究表明，ARHGAP4可能是一种生物标志物，与KIRC的进展、诊断和预后有关。结论：我们的研究表明，ARHGAP4可能是与KIRC的进展、诊断和预后相关的生物标志物，其生物学功能与肿瘤免疫浸润有关。

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来源期刊

Cancer Biomarkers ONCOLOGY-

CiteScore

5.20

自引率

3.20%

发文量

195

审稿时长

3 months

期刊介绍： Concentrating on molecular biomarkers in cancer research, Cancer Biomarkers publishes original research findings (and reviews solicited by the editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion. The disease markers may include, but are not limited to, genomic, epigenomic, proteomics, cellular and morphologic, and genetic factors predisposing to the disease or indicating the occurrence of the disease. Manuscripts on these factors or biomarkers, either in altered forms, abnormal concentrations or with abnormal tissue distribution leading to disease causation will be accepted.