Exploring the Role of Unconventional Post-Translational Modifications in Cancer Diagnostics and Therapy.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.2174/0113892037274615240528113148

Sayan Sharma, Oindrila Sarkar, Rajgourab Ghosh

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Abstract

Unconventional Post-Translational Modifications (PTMs) have gained increasing attention as crucial players in cancer development and progression. Understanding the role of unconventional PTMs in cancer has the potential to revolutionize cancer diagnosis, prognosis, and therapeutic interventions. These modifications, which include O-GlcNAcylation, glutathionylation, crotonylation, including hundreds of others, have been implicated in the dysregulation of critical cellular processes and signaling pathways in cancer cells. This review paper aims to provide a comprehensive analysis of unconventional PTMs in cancer as diagnostic markers and therapeutic targets. The paper includes reviewing the current knowledge on the functional significance of various conventional and unconventional PTMs in cancer biology. Furthermore, the paper highlights the advancements in analytical techniques, such as biochemical analyses, mass spectrometry and bioinformatic tools etc., that have enabled the detection and characterization of unconventional PTMs in cancer. These techniques have contributed to the identification of specific PTMs associated with cancer subtypes. The potential use of Unconventional PTMs as biomarkers will further help in better diagnosis and aid in discovering potent therapeutics. The knowledge about the role of Unconventional PTMs in a vast and rapidly expanding field will help in detection and targeted therapy of cancer.

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探索非常规翻译后修饰在癌症诊断和治疗中的作用。

非常规翻译后修饰（PTMs）作为癌症发生和发展过程中的关键角色，已受到越来越多的关注。了解非常规 PTM 在癌症中的作用有可能彻底改变癌症诊断、预后和治疗干预。这些修饰包括 O-GlcNA酰化、谷胱甘肽酰化、巴豆酰化以及其他数百种修饰，它们与癌细胞中关键细胞过程和信号通路的失调有关。本综述论文旨在全面分析癌症中作为诊断标记和治疗靶点的非常规 PTMs。论文回顾了目前关于各种常规和非常规 PTM 在癌症生物学中的功能意义的知识。此外，论文还强调了分析技术的进步，如生化分析、质谱分析和生物信息学工具等，这些技术使癌症中非常规 PTMs 的检测和表征成为可能。这些技术有助于确定与癌症亚型相关的特定 PTM。非常规 PTMs 作为生物标记物的潜在用途将进一步帮助更好地诊断和发现有效的治疗方法。了解非常规 PTM 在这个广阔而快速发展的领域中的作用将有助于癌症的检测和靶向治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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