Evaluation of pancreatic iodine uptake and related influential factors in multiphase dual-energy CT.

IF 4.7 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING European Radiology Pub Date : 2024-12-01 Epub Date: 2024-06-24 DOI:10.1007/s00330-024-10850-0

Chen Pan, Tao Yu, Heng Zhao, Jiani He, Xiaomei Lu, Haiyan Tang, Yang Hong, Chao Shang, Qijun Wu, Aoran Yang, Chunli Li, Minghui Zhou, Yu Shi

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Abstract

Objectives: To establish normative values and identify potential factors influencing pancreatic iodine uptake using dual-energy CT (DECT).

Materials and methods: This retrospective study included participants without pancreatic diseases undergoing DECT at two institutions with different platforms. Their protocols both included arterial phase (AP), portal venous phase (PP), and equilibrium phase (EP), defined as 35 s-40 s, 60 s-70 s, and 150 s-180 s after injection of contrast agent, respectively. Both iodine concentration (IC) and normalised IC (NIC) were measured. Demographic features, local measurements of the pancreas and visceral fat area (VFA) were considered as potential factors influencing iodine uptake using multivariate linear regression analyses.

Results: A total of 562 participants (median age 58 years [interquartile range: 47-67], with 282 men) were evaluated. The mean IC differed significantly between two institutions (all p < 0.001) across three contrast-enhanced phases, while the mean NIC showed no significant differences (all p > 0.05). The mean values of NIC were 0.22 at AP, 0.43 at PP and 0.45 at EP. NIC_AP was independently affected by VFA (β = 0.362, p < 0.001), smoking (β = -0.240, p = 0.001), and type-II diabetes (β = -0.449, p < 0.001); NIC_PP by VFA (β = -0.301, p = 0.017) and smoking (β = -0.291, p < 0.001); and NIC_EP by smoking (β = -0.154, p = 0.10) and alcohol consumption (β = -0.350, p < 0.001) with statistical power values over 0.81.

Conclusion: NIC values were consistent across institutions. Abdominal obesity, smoking, alcohol consumption, and diabetes are independent factors influencing pancreatic iodine uptake.

Clinical relevance statement: This study has provided reference normative values, influential factors and effective normalisation methods of pancreatic iodine uptake in multiphase dual-energy CT for future studies in this area as a new biological marker.

Key points: Evaluation of pancreatic iodine uptake measured by dual-energy CT is a promising method for future studies. Abdominal obesity, smoking, alcohol consumption, diabetes, and sex are independent factors influencing pancreatic iodine uptake. Utility of normalised iodine concentration is necessary to ensure the consistency across different institutions.

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多相双能 CT 中胰腺碘摄取量及相关影响因素评估

目的利用双能 CT（DECT）确定标准值并识别影响胰腺碘摄取的潜在因素：这项回顾性研究包括在两家拥有不同平台的机构接受 DECT 检查的无胰腺疾病患者。它们的方案都包括动脉期（AP）、门静脉期（PP）和平衡期（EP），分别定义为注射造影剂后 35 秒-40 秒、60 秒-70 秒和 150 秒-180 秒。对碘浓度（IC）和归一化 IC（NIC）进行了测量。通过多变量线性回归分析，将人口统计学特征、胰腺局部测量值和内脏脂肪面积（VFA）视为影响碘吸收的潜在因素：共评估了 562 名参与者（中位年龄 58 岁[四分位距：47-67]，男性 282 人）。两家机构的 IC 平均值差异很大（均为 P 0.05）。AP 的 NIC 平均值为 0.22，PP 为 0.43，EP 为 0.45。NICAP受VFA（β = 0.362，p PP受VFA（β = -0.301，p = 0.017）和吸烟（β = -0.291，p EP受吸烟（β = -0.154，p = 0.10）和饮酒（β = -0.350，p 结论）的独立影响：各机构的 NIC 值一致。腹部肥胖、吸烟、饮酒和糖尿病是影响胰腺摄碘量的独立因素：本研究提供了多相双能 CT 中胰腺摄碘量的参考标准值、影响因素和有效的归一化方法，为今后该领域的研究提供了新的生物标志物：要点：通过双能 CT 评估胰腺摄碘量是一种很有前途的研究方法。腹部肥胖、吸烟、饮酒、糖尿病和性别是影响胰腺摄碘量的独立因素。归一化碘浓度的实用性对于确保不同机构的一致性非常必要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Radiology 医学-核医学

CiteScore

11.60

自引率

8.50%

发文量

874

审稿时长

2-4 weeks

期刊介绍： European Radiology (ER) continuously updates scientific knowledge in radiology by publication of strong original articles and state-of-the-art reviews written by leading radiologists. A well balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes ER an indispensable source for current information in this field. This is the Journal of the European Society of Radiology, and the official journal of a number of societies. From 2004-2008 supplements to European Radiology were published under its companion, European Radiology Supplements, ISSN 1613-3749.