Sleep disorders in pediatric patients with agenesis of the corpus callosum.

IF 3.5 3区 医学 Q1 CLINICAL NEUROLOGY Journal of Clinical Sleep Medicine Pub Date : 2024-10-01 DOI:10.5664/jcsm.11234
Ashley Kwon, Payal Kenia Gu, Christina Zhang, Sally L Davidson Ward, Iris A Perez
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Abstract

Study objectives: There is limited information about sleep in agenesis of the corpus callosum (ACC). We aim to describe the sleep architecture and respiratory parameters of children with ACC.

Methods: We performed a retrospective study of 20 patients with ACC who had polysomnography between 2000 and 2023. Demographic data, body mass index or weight for length, associated conditions, and polysomnography findings were collected. National Sleep Foundation sleep quality indicators as well as increased polysomnography arousal index ≥ 10 events/h were used in the analysis. Fisher's exact test or unpaired t test was used to compare groups.

Results: Average age was 5.9 ± 5.4 years old. A total of 12/20 patients were male; 6/20 were overweight/obese; 14/20 had complete ACC, and 6/20 had partial ACC; 8/20 had seizures; 15/20 had ≥ 1 National Sleep Foundation poor sleep quality indicator (decreased sleep efficiency [45%], decreased rapid eye movement sleep [53%]); and 9/20 had increased arousals. Between complete and partial ACC, there was no difference in presence of ≥ 1 poor sleep quality indicator (P = .61), sleep efficiency (P = .34), rapid eye movement sleep (P = .28), and arousals (P = 1.0). 11/18 had obstructive sleep apnea (OSA); 5/11 had associated central sleep apnea. There was no difference in OSA between those with complete and partial ACC (P = 1.0). OSA was associated with children < 3 years old (P = .01).

Conclusions: Children with ACC have poor sleep quality, and many have OSA. There was no difference in sleep quality or presence of OSA between those with complete and partial ACC. OSA was seen more in younger children. Our study supports the need for screening of sleep-related disorders in patients with ACC.

Citation: Kwon A, Gu PK, Zhang C, Davidson Ward SL, Perez IA. Sleep disorders in pediatric patients with agenesis of the corpus callosum. J Clin Sleep Med. 2024;20(10):1663-1667.

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胼胝体发育不全儿科患者的睡眠障碍。
研究目的:有关胼胝体发育不全(ACC)患儿睡眠的信息非常有限。我们旨在描述 ACC 患儿的睡眠结构和呼吸参数:我们对 2000-2023 年间接受多导睡眠图(PSG)检查的 20 名 ACC 患者进行了回顾性研究。我们收集了人口统计学数据、体重指数(BMI)或身长体重、相关疾病和 PSG 结果。分析中使用了美国国家睡眠基金会(NSF)的睡眠质量指标以及唤醒指数≥10/h的 PSG 增加值。组间比较采用费雪精确检验或非配对 t 检验:平均年龄为(5.9 ± 5.4)岁;12/20 名患者为男性。6/20为超重/肥胖。14/20患者患有完全性ACC,6/20患者患有部分性ACC。8/20 人有癫痫发作。15/20 名患者的 NSF 睡眠质量指标≥1 项(SE 减少(45%),REM 减少(53%)),9/20 名患者的唤醒次数增加。完全和部分 ACC 患者在睡眠质量指标≥1 项(P= 0.61)、SE(P=0.34)、REM(P=0.28)和唤醒(P=1.0)方面没有差异。11/18患有阻塞性睡眠呼吸暂停(OSA);5/11伴有中枢性睡眠呼吸暂停。完全性和部分性 ACC 患者的 OSA 无差异(p=1.0)。结论:患有 ACC 的儿童睡眠质量很差,其中许多人患有 OSA。完全性和部分性 ACC 患儿在睡眠质量或是否患有 OSA 方面没有差异。OSA多见于年龄较小的儿童。我们的研究支持有必要对 ACC 患者进行睡眠相关疾病筛查。
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来源期刊
CiteScore
6.20
自引率
7.00%
发文量
321
审稿时长
1 months
期刊介绍: Journal of Clinical Sleep Medicine focuses on clinical sleep medicine. Its emphasis is publication of papers with direct applicability and/or relevance to the clinical practice of sleep medicine. This includes clinical trials, clinical reviews, clinical commentary and debate, medical economic/practice perspectives, case series and novel/interesting case reports. In addition, the journal will publish proceedings from conferences, workshops and symposia sponsored by the American Academy of Sleep Medicine or other organizations related to improving the practice of sleep medicine.
期刊最新文献
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