{"title":"Anti-A and anti-B titers in A, B and O whole blood donors: Beyond “dangerous O”","authors":"","doi":"10.1016/j.tracli.2024.06.007","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Hemolytic transfusion reactions (HTRs) pose significant risks in transfused patients, with anti-A and anti-B antibodies in donor plasma being potential contributing factors. Despite advancements in component preparation, HTRs remain a concern, particularly with apheresis-derived platelets. This study aimed to determine the prevalence of high anti-A and anti-B titers among A, B, and O blood group donors and to explore factors associated with high titers.</div></div><div><h3>Materials and Methods</h3><div>A cross-sectional observational study was conducted over 18 months, enrolling 978 participants from a tertiary care teaching hospital in Western India. Anti-A and anti-B titers were determined using the Conventional Tube Technique (CTT). Statistical analysis assessed correlations between high titers and demographic factors.</div></div><div><h3>Results</h3><div>The majority of participants were young males (98.8%). Prevalence of high titers for IgM anti-A was 12.2% and IgG anti-A was 2.5%. For anti-B, IgM titers were 2.3% and IgG titers were 0.2%. The prevalence of dangerous O was found to be 14.1%, while 3.52% and 10.5% of A and B blood group donors were found to have high titers, respectively. Factors associated with high titers included female gender, vegetarian diet, age <30 years, and O blood group.</div></div><div><h3>Conclusion</h3><div>The study sheds additional light and provides supplementary information regarding the prevalence and correlation of high anti-A and anti-B titers among O, A and B blood donors. Understanding these factors is crucial for optimizing transfusion safety protocols, including selective screening of platelet units and tailored transfusion strategies based on donor characteristics.</div></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"31 4","pages":"Pages 195-200"},"PeriodicalIF":16.4000,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1246782024000685","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Background and Objectives
Hemolytic transfusion reactions (HTRs) pose significant risks in transfused patients, with anti-A and anti-B antibodies in donor plasma being potential contributing factors. Despite advancements in component preparation, HTRs remain a concern, particularly with apheresis-derived platelets. This study aimed to determine the prevalence of high anti-A and anti-B titers among A, B, and O blood group donors and to explore factors associated with high titers.
Materials and Methods
A cross-sectional observational study was conducted over 18 months, enrolling 978 participants from a tertiary care teaching hospital in Western India. Anti-A and anti-B titers were determined using the Conventional Tube Technique (CTT). Statistical analysis assessed correlations between high titers and demographic factors.
Results
The majority of participants were young males (98.8%). Prevalence of high titers for IgM anti-A was 12.2% and IgG anti-A was 2.5%. For anti-B, IgM titers were 2.3% and IgG titers were 0.2%. The prevalence of dangerous O was found to be 14.1%, while 3.52% and 10.5% of A and B blood group donors were found to have high titers, respectively. Factors associated with high titers included female gender, vegetarian diet, age <30 years, and O blood group.
Conclusion
The study sheds additional light and provides supplementary information regarding the prevalence and correlation of high anti-A and anti-B titers among O, A and B blood donors. Understanding these factors is crucial for optimizing transfusion safety protocols, including selective screening of platelet units and tailored transfusion strategies based on donor characteristics.
背景和目的：溶血性输血反应（HTR）对输血患者构成重大风险，供体血浆中的抗 A 和抗 B 抗体是潜在的诱因。尽管成分制备技术不断进步，但溶血性输血反应仍是一个令人担忧的问题，尤其是无细胞血浆来源的血小板。本研究旨在确定高抗A和抗B滴度在A、B和O型血献血者中的流行率，并探讨与高滴度相关的因素：这项横断面观察研究历时 18 个月，从印度西部一家三级医疗教学医院招募了 978 名参与者。采用传统试管技术（CTT）测定抗 A 和抗 B 滴度。统计分析评估了高滴度与人口统计学因素之间的相关性：结果：大多数参与者为年轻男性（98.8%）。高滴度 IgM 抗 A 为 12.2%，IgG 抗 A 为 2.5%。抗 B 的 IgM 滴度为 2.3%，IgG 滴度为 0.2%。危险 O 型血的流行率为 14.1%，而 A 型和 B 型血献血者中分别有 3.52% 和 10.5% 滴度较高。与高滴度相关的因素包括女性性别、素食、年龄 结论：这项研究揭示了 O、A 和 B 型献血者中高抗 A 和抗 B 滴度的流行率和相关性，并提供了补充信息。了解这些因素对于优化输血安全方案至关重要，包括血小板单位的选择性筛查和基于献血者特征的定制输血策略。
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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