Serum lipid ratios as novel prognostic biomarkers for patients with locally advanced breast cancer treated with neoadjuvant therapy.

Postgraduate medicine Pub Date : 2024-06-01 Epub Date: 2024-06-24 DOI:10.1080/00325481.2024.2370235
Xinru Chen, Yingying Zhao, Yaohui Wang, Yumei Ye, Shuguang Xu, Liheng Zhou, Yanping Lin, Jingsong Lu, Wenjin Yin
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Abstract

Objectives: To investigate the association between lipid ratios and survival outcomes in patients with locally advanced breast cancer (LABC) undergoing neoadjuvant chemotherapy.

Method: This retrospective study included patients with LABC receiving neoadjuvant chemotherapy. Serum lipid levels were prospectively measured at baseline. Associations of triglyceride to total cholesterol (TG/TC), triglyceride to high-density lipoprotein (TG/HDL) and triglyceride to low-density lipoprotein (TG/LDL) ratios with prognosis were evaluated.

Results: Patients with high TG/TC (adjusted hazard ratio [aHR] = 2.47, 95% CI: 1.10, 5.56, p = 0.029), TG/HDL (aHR = 2.73, 95% CI: 1.16, 6.41, p = 0.021) and TG/LDL (aHR = 2.50, 95% CI: 1.11, 5.65, p = 0.027) ratios were more likely to experience disease-free survival (DFS) events. Subgroup analysis suggested that the prognostic impact of lipid ratios was more pronounced in patients with negative HER2 status or those at a high risk of recurrence (e.g. clinical stage III, Ki67 > 30%). Additionally, higher lipid ratios tended to indicate early DFS events (0 ~ 2 years) (TG/TC p = 0.021, TG/HDL p = 0.046, TG/LDL p < 0.001), and the TG/LDL ratio demonstrated the best predictive efficacy (TG/TC vs. TG/HDL vs. TG/LDL, 1-year AUC: 0.724 vs. 0.676 vs. 0.846, 2-year AUC: 0.653 vs. 0.638 vs. 0.708).

Conclusion: Baseline serum TG/TC, TG/HDL and TG/LDL ratios were independent prognostic factors in patients with LABC undergoing neoadjuvant therapy. However, their utility in predicting the early DFS events warrants further investigation.

Clinical trial registration: NCT05621564.

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血清脂质比率作为接受新辅助治疗的局部晚期乳腺癌患者的新型预后生物标志物。
目的研究接受新辅助化疗的局部晚期乳腺癌(LABC)患者的血脂比率与生存结果之间的关系:这项回顾性研究包括接受新辅助化疗的局部晚期乳腺癌患者。在基线时对血清脂质水平进行了前瞻性测量。评估甘油三酯与总胆固醇(TG/TC)、甘油三酯与高密度脂蛋白(TG/HDL)以及甘油三酯与低密度脂蛋白(TG/LDL)之比与预后的关系:TG/TC(调整后危险比 [aHR] = 2.47,95% CI:1.10,5.56,p = 0.029)、TG/HDL(aHR = 2.73,95% CI:1.16,6.41,p = 0.021)和TG/LDL(aHR = 2.50,95% CI:1.11,5.65,p = 0.027)比率高的患者更有可能发生无病生存(DFS)事件。亚组分析表明,血脂比率对HER2状态阴性或复发风险高(如临床III期、Ki67>30%)的患者的预后影响更明显。此外,较高的血脂比率往往预示着早期 DFS 事件(0 ~ 2 年)(TG/TC p = 0.021,TG/HDL p = 0.046,TG/LDL p 结论:基线血清 TG/TC、TG/HDL 和 TG/LDL 比率是接受新辅助治疗的 LABC 患者的独立预后因素。然而,它们在预测早期 DFS 事件方面的作用还需要进一步研究:临床试验注册:NCT05621564。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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