Investigating the relationship of theory of mind and empathy with neuroimaging, neuropsychological, and neuropsychiatric data in persons with multiple sclerosis.

IF 1.7 4区医学 Q4 NEUROSCIENCES Social Neuroscience Pub Date : 2024-04-01 Epub Date: 2024-06-25 DOI:10.1080/17470919.2024.2371006

Taha Aslan, Asiye Tuba Ozdogar, Ozge Sagici, Pinar Yigit, Nabi Zorlu, Emre Bora, Serkan Ozakbas

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Abstract

Theory of Mind (ToM) is understanding others' minds. Empathy is an insight into emotions and feelings of others. Persons with multiple sclerosis (pwMS) may experience impairment in ToM and empathy. To investigate ToM, empathy, and their relationship with neuroimaging, neuropsychological, and neuropsychiatric data. 41 pwMS and 41 HC were assessed using RMET for ToM, EQ, BICAMS, HADS. Cortical and subcortical gray matter volumes were calculated with Freesurfer from 3T MRI scans. pwMS showed lower EQ scores (44.82 ± 11.9 vs 51.29 ± 9.18, p = 0.02) and worse RMET performance (22.37 ± 4.09 vs 24,47 ± 2.93, p = 0.011). Anxiety and depression were higher in pwMS. EQ correlated with subcortical (amygdala) and cortical (anterior cingulate) volumes. RMET correlated with cortical volumes (posterior cingulate, lingual). In regression analysis, amygdala volume was the single predictor of empathy performance (p = 0.041). There were no significant correlations between social cognitive tests and general cognition. A weak negative correlation was found between EQ and the level of anxiety (r = -0.342, p = 0.038) The present study indicates that pwMS have impairment on ToM and empathy. The performance of ToM and empathy in MS is linked to the volumes of critical brain areas involved in social cognition.

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研究多发性硬化症患者的思维理论和移情能力与神经影像学、神经心理学和神经精神病学数据之间的关系。

心智理论（ToM）是对他人心智的理解。移情是对他人情绪和情感的洞察。多发性硬化症患者（pwMS）的心智理论和移情能力可能会受损。调查 ToM、移情及其与神经影像学、神经心理学和神经精神病学数据的关系。使用 RMET 对 41 名 pwMS 和 41 名 HC 进行了 ToM、EQ、BICAMS 和 HADS 评估。患者的情商得分较低（44.82 ± 11.9 vs 51.29 ± 9.18，p = 0.02），RMET表现较差（22.37 ± 4.09 vs 24,47 ± 2.93，p = 0.011）。焦虑和抑郁程度在男性和女性患者中更高。情商与皮质下（杏仁核）和皮质（前扣带回）体积相关。RMET 与皮质体积（扣带回后部、舌骨）相关。在回归分析中，杏仁核体积是预测移情表现的唯一指标（p = 0.041）。社会认知测试与一般认知之间没有明显的相关性。情商与焦虑程度之间存在微弱的负相关（r = -0.342，p = 0.038）。多发性硬化症患者 ToM 和移情能力的表现与参与社会认知的关键脑区的体积有关。

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来源期刊

Social Neuroscience 医学-神经科学

CiteScore

3.40

自引率

5.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Social Neuroscience features original empirical Research Papers as well as targeted Reviews, Commentaries and Fast Track Brief Reports that examine how the brain mediates social behavior, social cognition, social interactions and relationships, group social dynamics, and related topics that deal with social/interpersonal psychology and neurobiology. Multi-paper symposia and special topic issues are organized and presented regularly as well. The goal of Social Neuroscience is to provide a place to publish empirical articles that intend to further our understanding of the neural mechanisms contributing to the development and maintenance of social behaviors, or to understanding how these mechanisms are disrupted in clinical disorders.