Matrikines in the skin: Origin, effects, and therapeutic potential

IF 12 1区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmacology & Therapeutics Pub Date : 2024-06-23 DOI:10.1016/j.pharmthera.2024.108682
Jonathan P. Sirois, Andrea Heinz
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Abstract

The extracellular matrix (ECM) represents a complex multi-component environment that has a decisive influence on the biomechanical properties of tissues and organs. Depending on the tissue, ECM components are subject to a homeostasis of synthesis and degradation, a subtle interplay that is influenced by external factors and the intrinsic aging process and is often disturbed in pathologies. Upon proteolytic cleavage of ECM proteins, small bioactive peptides termed matrikines can be formed. These bioactive peptides play a crucial role in cell signaling and contribute to the dynamic regulation of both physiological and pathological processes such as tissue remodeling and repair as well as inflammatory responses. In the skin, matrikines exert an influence for instance on cell adhesion, migration, and proliferation as well as vasodilation, angiogenesis and protein expression. Due to their manifold functions, matrikines represent promising leads for developing new therapeutic options for the treatment of skin diseases. This review article gives a comprehensive overview on matrikines in the skin, including their origin in the dermal ECM, their biological effects and therapeutic potential for the treatment of skin pathologies such as melanoma, chronic wounds and inflammatory skin diseases or for their use in anti-aging cosmeceuticals.

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皮肤中的母树碱:起源、作用和治疗潜力。
细胞外基质(ECM)是一种复杂的多成分环境,对组织和器官的生物力学特性具有决定性影响。根据组织的不同,ECM 成分的合成和降解处于平衡状态,这种微妙的相互作用受到外部因素和内在衰老过程的影响,并经常在病理情况下受到干扰。当 ECM 蛋白质被蛋白酶裂解时,就会形成小的生物活性肽,即 matrikines。这些生物活性肽在细胞信号传导中起着至关重要的作用,有助于动态调节生理和病理过程,如组织重塑和修复以及炎症反应。例如,在皮肤中,消旋肽对细胞粘附、迁移、增殖以及血管扩张、血管生成和蛋白质表达都有影响。由于它们具有多方面的功能,母树蛋白是开发治疗皮肤病新疗法的有前途的线索。这篇综述文章全面概述了皮肤中的母树蛋白,包括它们在真皮 ECM 中的起源、生物效应以及在治疗黑色素瘤、慢性伤口和炎症性皮肤病等皮肤疾病或用于抗衰老药妆方面的治疗潜力。
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来源期刊
CiteScore
23.00
自引率
0.70%
发文量
222
审稿时长
90 days
期刊介绍: Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.
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