Tracking the Spread of the BA.2.86 Lineage in Italy Through Wastewater Analysis

IF 4.1 2区农林科学 Q2 ENVIRONMENTAL SCIENCES Food and Environmental Virology Pub Date : 2024-06-25 DOI:10.1007/s12560-024-09607-1

C. Veneri, D. Brandtner, P. Mancini, G. Bonanno Ferraro, M. Iaconelli, E. Suffredini, M. Petrillo, G. Leoni, V. Paracchini, B. M. Gawlik, A. Marchini, the SARI Network, G. La Rosa

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Abstract

The emergence of new SARS-CoV-2 variants poses challenges to global surveillance efforts, necessitating swift actions in their detection, evaluation, and management. Among the most recent variants, Omicron BA.2.86 and its sub-lineages have gained attention due to their potential immune evasion properties. This study describes the development of a digital PCR assay for the rapid detection of BA.2.86 and its descendant lineages, in wastewater samples. By using this assay, we analyzed wastewater samples collected in Italy from September 2023 to January 2024. Our analysis revealed the presence of BA.2.86 lineages already in October 2023 with a minimal detection rate of 2% which then rapidly increased, becoming dominant by January 2024, accounting for a prevalence of 62%. The findings emphasize the significance of wastewater-based surveillance in tracking emerging variants and underscore the efficacy of targeted digital PCR assays for environmental monitoring.

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通过废水分析追踪 BA.2.86 血统在意大利的传播。

新的 SARS-CoV-2 变体的出现给全球监测工作带来了挑战，需要迅速采取行动对其进行检测、评估和管理。在最近的变种中，Omicron BA.2.86 及其亚系因其潜在的免疫逃避特性而备受关注。本研究介绍了一种用于快速检测废水样本中 BA.2.86 及其子系的数字 PCR 检测方法。通过使用这种检测方法，我们分析了 2023 年 9 月至 2024 年 1 月期间在意大利采集的废水样本。分析结果表明，BA.2.86 族系在 2023 年 10 月就已出现，最低检出率为 2%，随后迅速增加，到 2024 年 1 月已成为主要族系，检出率高达 62%。这些发现强调了基于废水的监测在追踪新变种方面的重要性，并突出了有针对性的数字 PCR 检测在环境监测方面的功效。

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来源期刊

Food and Environmental Virology ENVIRONMENTAL SCIENCES-MICROBIOLOGY

CiteScore

6.50

自引率

2.90%

发文量

审稿时长

1 months

期刊介绍： Food and Environmental Virology publishes original articles, notes and review articles on any aspect relating to the transmission of pathogenic viruses via the environment (water, air, soil etc.) and foods. This includes epidemiological studies, identification of novel or emerging pathogens, methods of analysis or characterisation, studies on survival and elimination, and development of procedural controls for industrial processes, e.g. HACCP plans. The journal will cover all aspects of this important area, and encompass studies on any human, animal, and plant pathogenic virus which is capable of transmission via the environment or food.