The Impact of Blood and Urine Biomarkers on Age-Related Macular Degeneration: Insights from Mendelian Randomization and Cross-sectional Study from NHANES.

IF 3.7 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS Biological Procedures Online Pub Date : 2024-06-25 DOI:10.1186/s12575-024-00248-z

Wang Jingzhi, Xuehao Cui

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Abstract

Introduction: Age-related macular degeneration (AMD) is a leading cause of blindness, affecting millions worldwide. Its complex pathogenesis involves a variety of risk factors, including lipid metabolism and inflammation. This study aims to elucidate the causal relationships between biomarkers related to these processes and AMD, leveraging Mendelian randomization (MR) and cross-sectional analysis from the National Health and Nutrition Examination Survey (NHANES).

Method: We conducted a two-phase study, initially using MR to explore the causality between 35 biomarkers and various AMD subtypes, followed by observational analysis with NHANES data to validate these findings.

Results: MR analysis identified a protective role of TG and a risk factor role of HDL-C and CRP in AMD development. NHANES data corroborated these findings, highlighting a nuanced relationship between these biomarkers and AMD. Notably, lipid metabolism-related biomarkers showed stronger associations with early AMD, whereas CRP's significance was pronounced in late AMD.

Conclusion: This comprehensive analysis, combining MR with NHANES data, reinforces the importance of lipid metabolism and inflammation in AMD's etiology. Future research should further investigate these biomarkers' mechanisms and their potential as therapeutic targets for AMD prevention and treatment.

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血液和尿液生物标志物对年龄相关性黄斑变性的影响：孟德尔随机化和 NHANES 横截面研究的启示。

导言：老年性黄斑变性（AMD）是导致失明的主要原因，影响着全球数百万人。其复杂的发病机制涉及多种风险因素，包括脂质代谢和炎症。本研究旨在利用孟德尔随机法（MR）和美国国家健康与营养调查（NHANES）的横断面分析，阐明与这些过程相关的生物标志物与老年性黄斑变性之间的因果关系：我们分两个阶段进行了研究，首先利用孟德尔随机分析法探讨了 35 种生物标志物与各种 AMD 亚型之间的因果关系，然后利用 NHANES 数据进行了观察分析，以验证这些发现：结果：磁共振分析确定了总胆固醇的保护作用以及高密度脂蛋白胆固醇和 CRP 的风险因素作用。NHANES 数据证实了这些发现，并强调了这些生物标志物与 AMD 之间的微妙关系。值得注意的是，脂质代谢相关生物标志物与早期AMD的关联性更强，而CRP在晚期AMD中的意义则更为明显：结论：这项综合分析结合了 MR 和 NHANES 数据，加强了脂质代谢和炎症在 AMD 病因中的重要性。未来的研究应进一步探讨这些生物标志物的作用机制及其作为预防和治疗 AMD 的治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Procedures Online 生物-生化研究方法

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： iological Procedures Online publishes articles that improve access to techniques and methods in the medical and biological sciences. We are also interested in short but important research discoveries, such as new animal disease models. Topics of interest include, but are not limited to: Reports of new research techniques and applications of existing techniques Technical analyses of research techniques and published reports Validity analyses of research methods and approaches to judging the validity of research reports Application of common research methods Reviews of existing techniques Novel/important product information Biological Procedures Online places emphasis on multidisciplinary approaches that integrate methodologies from medicine, biology, chemistry, imaging, engineering, bioinformatics, computer science, and systems analysis.