Domain 5 of Beta 2 glycoprotein I: Friend or foe in health? Context matters

IF 4.5 3区 医学 Q2 IMMUNOLOGY Clinical immunology Pub Date : 2024-06-23 DOI:10.1016/j.clim.2024.110282
Bill Giannakopoulos , Steven A. Krilis
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Abstract

Beta 2 glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome, an autoimmune disorder characterized by thrombotic and obstetric complications. The autoantibodies that target beta 2 glycoprotein I are pathogenic and contribute to disease pathogenesis. The β2GPI molecule is composed of 5 domains that are numbered 1 through to 5. Autoantibodies bind mainly to domain 1 whereas the majority of the biological functions of the β2GPI molecule in diverse processes such as apoptotic cell clearance, complement regulation, lipopolysaccharide clearance and anticoagulation have been localised to domain 5 and its unique biochemistry, reviewed in this article. The role of purified domain 5 peptide as a potential therapeutic agent in APS and ischemia reperfusion injury is discussed.

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Beta 2 糖蛋白 I 的结构域 5:健康的敌人还是朋友?背景很重要。
β2糖蛋白I(B2GPI)是抗磷脂综合征的主要自身抗原,抗磷脂综合征是一种以血栓和产科并发症为特征的自身免疫性疾病。以β2糖蛋白I为靶点的自身抗体具有致病性,并有助于疾病的发病。B2GPI 分子由编号为 1 至 5 的 5 个结构域组成。自身抗体主要与结构域 1 结合,而 B2GPI 分子在凋亡细胞清除、补体调节、脂多糖清除和抗凝等不同过程中的大部分生物功能都被定位在结构域 5 及其独特的生物化学上,本综述文章将对其进行综述。文章还讨论了纯化的结构域 5 肽在 APS 和缺血再灌注损伤中作为潜在治疗药物的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical immunology
Clinical immunology 医学-免疫学
CiteScore
12.30
自引率
1.20%
发文量
212
审稿时长
34 days
期刊介绍: Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.
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