Molecular and Evolutionary Analysis of RNA-Protein Interactions in Telomerase Regulation.

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Non-Coding RNA Pub Date : 2024-06-18 DOI:10.3390/ncrna10030036
Justin A Davis, Kausik Chakrabarti
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Abstract

Telomerase is an enzyme involved in the maintenance of telomeres. Telomere shortening due to the end-replication problem is a threat to the genome integrity of all eukaryotes. Telomerase inside cells depends on a myriad of protein-protein and RNA-protein interactions to properly assemble and regulate the function of the telomerase holoenzyme. These interactions are well studied in model eukaryotes, like humans, yeast, and the ciliated protozoan known as Tetrahymena thermophila. Emerging evidence also suggests that deep-branching eukaryotes, such as the parasitic protist Trypanosoma brucei require conserved and novel RNA-binding proteins for the assembly and function of their telomerase. In this review, we will discuss telomerase regulatory pathways in the context of telomerase-interacting proteins, with special attention paid to RNA-binding proteins. We will discuss these interactors on an evolutionary scale, from parasitic protists to humans, to provide a broader perspective on the extensive role that protein-protein and RNA-protein interactions play in regulating telomerase activity in eukaryotes.

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端粒酶调控中 RNA 蛋白相互作用的分子和进化分析。
端粒酶是一种参与端粒维护的酶。末端复制问题导致的端粒缩短威胁着所有真核生物基因组的完整性。细胞内的端粒酶依赖于大量的蛋白质-蛋白质和核糖核酸-蛋白质相互作用来正确组装和调节端粒酶全酶的功能。这些相互作用在模式真核生物(如人类、酵母和纤毛原生动物嗜热四膜虫)中得到了很好的研究。新的证据还表明,深枝真核生物(如寄生原生动物布氏锥虫)需要保守的和新型的 RNA 结合蛋白来组装端粒酶并发挥其功能。在这篇综述中,我们将从端粒酶相互作用蛋白的角度讨论端粒酶的调控途径,并特别关注 RNA 结合蛋白。我们将从寄生原生动物到人类的进化尺度来讨论这些相互作用蛋白,从而以更广阔的视角来探讨蛋白质与蛋白质以及RNA与蛋白质之间的相互作用在调节真核生物端粒酶活性方面所发挥的广泛作用。
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来源期刊
Non-Coding RNA
Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
6.70
自引率
4.70%
发文量
74
审稿时长
10 weeks
期刊介绍: Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.
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