REM and NREM Sleep Parasomnia in Anti-NMDA Receptor Encephalitis.

IF 7.8 1区医学 Q1 CLINICAL NEUROLOGY Neurology® Neuroimmunology & Neuroinflammation Pub Date : 2024-09-01 Epub Date: 2024-06-25 DOI:10.1212/NXI.0000000000200203

Luis Ribeiro, Dimitri Psimaras, Raphael Vollhardt, Jerome Honnorat, Aurélie Méneret, Sophie Demeret, Adam Celier, Nefeli E Valyraki, Louis Cousyn, Loic Le Guennec, Isabelle Arnulf, Ana Z Gales

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Abstract

Objectives: Encephalitis with anti-N-methyl-d-aspartate receptor antibodies (anti-NMDARe) is a rare disorder characterized by cognitive impairment, psychosis, seizures, and abnormal movements. Abnormal behaviors during REM sleep have not been described in anti-NMDARe.

Methods: Patients were monitored by video-polysomnography on a first night followed by multiple sleep latency tests and 18 hours of bed rest.

Results: Two patients with anti-NMDARe developed during the acute and postacute phase parasomnias including REM sleep behavior disorder and continuous finalistic quiet gesturing during a mixed N2/R sleep. The parasomnia disorder was improved by gabapentin and clonazepam.

Discussion: Video-polysomnography avoids misdiagnosing these parasomnia behaviors for seizure or movement disorders and allows adequate treatment.

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抗NMDA受体脑炎患者的快速眼动和非快速眼动睡眠妄想症

目的：抗 N-甲基-d-天冬氨酸受体抗体脑炎（anti-NMDARe）是一种罕见的疾病，以认知障碍、精神病、癫痫发作和异常运动为特征。抗 NMDARe 患者在快速动眼期睡眠中的异常行为尚未见报道：方法：患者在第一晚接受视频多导睡眠监测，随后进行多次睡眠潜伏期测试，并卧床休息 18 小时：结果：两名抗NMDARe患者在急性期和急性期后出现了寄生虫症状，包括快速眼动睡眠行为障碍和在N2/R混合睡眠中持续做最后的安静手势。讨论：讨论：视频多导睡眠图检查可避免将这些寄生虫睡眠行为误诊为癫痫发作或运动障碍，并可进行适当的治疗。

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来源期刊

Neurology® Neuroimmunology & Neuroinflammation Neuroscience-Neurology

CiteScore

15.60

自引率

2.30%

发文量

219

审稿时长

8 weeks

期刊介绍： Neurology Neuroimmunology & Neuroinflammation is an official journal of the American Academy of Neurology. Neurology: Neuroimmunology & Neuroinflammation will be the premier peer-reviewed journal in neuroimmunology and neuroinflammation. This journal publishes rigorously peer-reviewed open-access reports of original research and in-depth reviews of topics in neuroimmunology & neuroinflammation, affecting the full range of neurologic diseases including (but not limited to) Alzheimer's disease, Parkinson's disease, ALS, tauopathy, and stroke; multiple sclerosis and NMO; inflammatory peripheral nerve and muscle disease, Guillain-Barré and myasthenia gravis; nervous system infection; paraneoplastic syndromes, noninfectious encephalitides and other antibody-mediated disorders; and psychiatric and neurodevelopmental disorders. Clinical trials, instructive case reports, and small case series will also be featured.