The effectiveness of chia seed in improving glycemic status: A systematic review and meta-analysis

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-06-01 DOI:10.1016/j.dsx.2024.103065
Pedram Pam , Iman El Sayed , Sanaz Asemani , Parsa Jamilian , Meysam Zarezadeh , Zohreh Ghoreishy
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Abstract

Aims

This systematic review and meta-analysis aims to evaluate the effectiveness of chia seeds in improving glycemic status, including fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and insulin.

Methods

A comprehensive literature search was conducted on PubMed, Scopus, Web of Science, Cochrane, and Google Scholar up to January 2024. Randomized controlled trials (RCTs) assessing the effect of chia seeds on FBG, HbA1c, and/or insulin that meet our eligibility criteria were included. Version 2 of the Cochrane risk-of-bias tool (RoB2) was used to assess the quality of the included studies. Data were extracted and analyzed using a random-effects model and reported as weighted mean differences (WMD) with 95 % confidence intervals (CI). Subgroup and sensitivity analyses were also performed. The registration number was CRD42023441766.

Results

Out of 341 articles retrieved from the initial search, 8 RCTs (with 10 arms) involving 362 participants were included in the meta-analysis. The results showed that chia consumption had no significant effect on FBG (WMD: 0.79 %; 95 % CI: −0.97 to 2.55; p = 0.38), HbA1c (WMD: −0.12 %; 95 % CI: −0.27 to 0.02; p = 0.09), and insulin (WMD:1.23 %; 95 % CI: −1.77 to 4.22; p = 0.42).

Conclusions

Chia seed consumption shows no significant impact on FBG, HbA1c, and insulin levels. This study is limited by the small number of studies in the meta-analysis and the significant heterogeneity among them, necessitating further research with larger sample sizes.

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奇异籽在改善血糖状况方面的功效:系统回顾和荟萃分析。
目的:本系统综述和荟萃分析旨在评估奇异籽在改善血糖状况(包括空腹血糖(FBG)、糖化血红蛋白(HbA1c)和胰岛素)方面的有效性:方法:在 PubMed、Scopus、Web of Science、Cochrane 和 Google Scholar 上对截至 2024 年 1 月的文献进行了全面检索。纳入符合资格标准的评估奇异籽对 FBG、HbA1c 和/或胰岛素影响的随机对照试验(RCT)。科克伦偏倚风险工具(RoB2)第 2 版用于评估纳入研究的质量。采用随机效应模型提取和分析数据,并以加权平均差 (WMD) 和 95% 置信区间 (CI) 的形式进行报告。此外,还进行了分组分析和敏感性分析。注册编号为 CRD42023441766:在最初检索到的 341 篇文章中,有 8 项 RCT(共 10 个研究组)被纳入荟萃分析,涉及 362 名参与者。结果显示,食用奇异籽对 FBG(WMD:0.79 %;95 % CI:-0.97 至 2.55;p = 0.38)、HbA1c(WMD:-0.12 %;95 % CI:-0.27 至 0.02;p = 0.09)和胰岛素(WMD:1.23 %;95 % CI:-1.77 至 4.22;p = 0.42)没有显著影响:结论:食用奇异籽对 FBG、HbA1c 和胰岛素水平没有明显影响。由于荟萃分析中的研究数量较少,且这些研究之间存在明显的异质性,因此本研究受到了一定的限制,有必要进行样本量更大的进一步研究。
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来源期刊
CiteScore
22.90
自引率
2.00%
发文量
248
审稿时长
51 days
期刊介绍: Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.
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