Versatile JMJD proteins: juggling histones and much more

IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI:10.1016/j.tibs.2024.06.009
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Abstract

Jumonji C domain-containing (JMJD) proteins are found in bacteria, fungi, animals, and plants. They belong to the 2-oxoglutarate-dependent oxygenase superfamily and are endowed with various enzymatic activities, including demethylation of histones and hydroxylation of non-histone proteins. Many JMJD proteins are involved in the epigenetic control of gene expression, yet they also modulate a myriad other cellular processes. In this review we focus on the 33 human JMJD proteins and their established and controversial catalytic properties, survey their epigenetic and non-epigenetic functions, emphasize their contribution to sex-specific disease differences, and highlight how they sense metabolic changes. All this underlines not only their key roles in development and homeostasis, but also that JMJD proteins are destined to become drug targets in multiple diseases.

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多用途 JMJD 蛋白:组蛋白和更多杂耍。
含 Jumonji C 结构域的蛋白质(JMJD)存在于细菌、真菌、动物和植物中。它们属于 2-氧代戊二酸依赖性加氧酶超家族,具有多种酶活性,包括组蛋白的去甲基化和非组蛋白的羟基化。许多 JMJD 蛋白参与了基因表达的表观遗传学控制,但它们也调节着无数其他细胞过程。在这篇综述中,我们将重点介绍 33 种人类 JMJD 蛋白及其既有的和有争议的催化特性,考察它们的表观遗传和非表观遗传功能,强调它们对性别特异性疾病差异的贡献,并着重介绍它们如何感知新陈代谢的变化。所有这一切不仅强调了它们在发育和体内平衡中的关键作用,而且还表明 JMJD 蛋白注定会成为多种疾病的药物靶点。
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来源期刊
Trends in Biochemical Sciences
Trends in Biochemical Sciences 生物-生化与分子生物学
CiteScore
22.90
自引率
0.70%
发文量
148
审稿时长
6-12 weeks
期刊介绍: For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.
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