Current Position of Gliclazide and Sulfonylureas in the Contemporary Treatment Paradigm for Type 2 Diabetes: A Scoping Review.

IF 3.8 3区医学 Q2 Medicine Diabetes Therapy Pub Date : 2024-08-01 Epub Date: 2024-06-27 DOI:10.1007/s13300-024-01612-8

Ibrahim Sahin, Okan Bakiner, Tevfik Demir, Ramazan Sari, Aysegul Atmaca

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Abstract

The increasing burden of type 2 diabetes (T2D), in relation to alarming rise in the prevalence; challenges in the diagnosis, prevention, and treatment; as well as the substantial impact of disease on longevity and quality of life, is a major concern in healthcare worldwide. Sulfonylureas (SUs) have been a cornerstone of T2D pharmacotherapy for over 60 years as oral antidiabetic drugs (OADs), while the newer generation SUs, such as gliclazide modified release (MR), are known to be associated with low risk of hypoglycemia in addition to the cardiovascular neutrality. This scoping review aimed to specifically address the current position of gliclazide MR among other SUs in the contemporary treatment paradigm for T2D and to provide a practical guidance document to assist clinicians in using gliclazide MR in real-life clinical practice. The main topics addressed in this paper include the role of early and sustained glycemic control and use of SUs in T2D management, the properties of gliclazide MR in relation to its effectiveness and safety, the use of gliclazide therapy in special populations, and the place of SUs as a class and gliclazide MR specifically in the current T2D treatment algorithm.

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格列齐特和磺脲类药物在当代 2 型糖尿病治疗范例中的当前地位：范围界定综述》。

2 型糖尿病（T2D）的发病率急剧上升，诊断、预防和治疗面临挑战，对寿命和生活质量造成严重影响，因此，2 型糖尿病的负担日益加重，成为全球医疗保健领域的一个主要问题。60多年来，磺脲类药物（SU）作为口服抗糖尿病药物（OAD）一直是T2D药物治疗的基石，而新一代的磺脲类药物，如格列齐特改良释放型（MR），除了对心血管无影响外，还具有低血糖的低风险性。本范围界定综述旨在具体探讨格列齐特（MR）在当代 T2D 治疗范例中与其他 SUs 相比的当前地位，并提供一份实用的指导文件，以协助临床医生在实际临床实践中使用格列齐特（MR）。本文讨论的主要议题包括：早期和持续血糖控制以及使用 SUs 在 T2D 治疗中的作用、格列齐特 MR 的有效性和安全性特性、格列齐特疗法在特殊人群中的应用，以及 SUs 作为一类药物，特别是格列齐特 MR 在当前 T2D 治疗方案中的地位。

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来源期刊

Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.90

自引率

7.90%

发文量

130

审稿时长

6 weeks

期刊介绍： Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.