The immune microenvironment of lung adenocarcinoma featured with ground-glass nodules.

IF 2.3 3区 医学 Q3 ONCOLOGY Thoracic Cancer Pub Date : 2024-07-01 Epub Date: 2024-06-24 DOI:10.1111/1759-7714.15380
Changtai Zhao, Rongxin Xiao, Hongming Jin, Xiao Li
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Abstract

Early-stage lung cancer is now more commonly identified in the form of ground-glass nodules (GGNs). Presently, the treatment of lung cancer with GGNs mainly depends on surgery; however, issues still exist such as overtreatment and delayed treatment due to the nonuniform standard of follow-up. Therefore, the discovery of a noninvasive treatment could expand the treatment repertoire of ground-glass nodular lung cancer and benefit the prognosis of patients. Immunotherapy has recently emerged as a new promising approach in the field of lung cancer treatment. Thus, this study presents a comprehensive review of the immune microenvironment of lung cancer with GGNs and describes the functions and characteristics of various immune cells involved, aiming to provide guidance for the clinical identification of novel immunotherapeutic targets.

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以磨玻璃结节为特征的肺腺癌免疫微环境。
目前,早期肺癌多以磨玻璃结节(GGN)的形式出现。目前,肺癌磨玻璃结节的治疗主要依靠手术,但由于随访标准不统一,过度治疗和延误治疗等问题依然存在。因此,非侵入性治疗方法的发现可以扩大磨玻璃结节性肺癌的治疗范围,有利于患者的预后。最近,免疫疗法已成为肺癌治疗领域中一种前景广阔的新方法。因此,本研究全面综述了地玻璃结节性肺癌的免疫微环境,并描述了参与其中的各种免疫细胞的功能和特点,旨在为临床确定新型免疫治疗靶点提供指导。
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来源期刊
Thoracic Cancer
Thoracic Cancer ONCOLOGY-RESPIRATORY SYSTEM
CiteScore
5.20
自引率
3.40%
发文量
439
审稿时长
2 months
期刊介绍: Thoracic Cancer aims to facilitate international collaboration and exchange of comprehensive and cutting-edge information on basic, translational, and applied clinical research in lung cancer, esophageal cancer, mediastinal cancer, breast cancer and other thoracic malignancies. Prevention, treatment and research relevant to Asia-Pacific is a focus area, but submissions from all regions are welcomed. The editors encourage contributions relevant to prevention, general thoracic surgery, medical oncology, radiology, radiation medicine, pathology, basic cancer research, as well as epidemiological and translational studies in thoracic cancer. Thoracic Cancer is the official publication of the Chinese Society of Lung Cancer, International Chinese Society of Thoracic Surgery and is endorsed by the Korean Association for the Study of Lung Cancer and the Hong Kong Cancer Therapy Society. The Journal publishes a range of article types including: Editorials, Invited Reviews, Mini Reviews, Original Articles, Clinical Guidelines, Technological Notes, Imaging in thoracic cancer, Meeting Reports, Case Reports, Letters to the Editor, Commentaries, and Brief Reports.
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