The immune microenvironment of lung adenocarcinoma featured with ground-glass nodules.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-07-01 Epub Date: 2024-06-24 DOI:10.1111/1759-7714.15380
Changtai Zhao, Rongxin Xiao, Hongming Jin, Xiao Li
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Abstract

Early-stage lung cancer is now more commonly identified in the form of ground-glass nodules (GGNs). Presently, the treatment of lung cancer with GGNs mainly depends on surgery; however, issues still exist such as overtreatment and delayed treatment due to the nonuniform standard of follow-up. Therefore, the discovery of a noninvasive treatment could expand the treatment repertoire of ground-glass nodular lung cancer and benefit the prognosis of patients. Immunotherapy has recently emerged as a new promising approach in the field of lung cancer treatment. Thus, this study presents a comprehensive review of the immune microenvironment of lung cancer with GGNs and describes the functions and characteristics of various immune cells involved, aiming to provide guidance for the clinical identification of novel immunotherapeutic targets.

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以磨玻璃结节为特征的肺腺癌免疫微环境。
目前,早期肺癌多以磨玻璃结节(GGN)的形式出现。目前,肺癌磨玻璃结节的治疗主要依靠手术,但由于随访标准不统一,过度治疗和延误治疗等问题依然存在。因此,非侵入性治疗方法的发现可以扩大磨玻璃结节性肺癌的治疗范围,有利于患者的预后。最近,免疫疗法已成为肺癌治疗领域中一种前景广阔的新方法。因此,本研究全面综述了地玻璃结节性肺癌的免疫微环境,并描述了参与其中的各种免疫细胞的功能和特点,旨在为临床确定新型免疫治疗靶点提供指导。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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