Health status and quality of life before critical illness: Northern Finland Birth Cohort 1966 study.

IF 1.9 4区医学 Q2 ANESTHESIOLOGY Acta Anaesthesiologica Scandinavica Pub Date : 2024-06-28 DOI:10.1111/aas.14490

Miikka Niittyvuopio, Siiri Hietanen, Janne Liisanantti, Michael Spalding, Juha Auvinen, Tero Ala-Kokko

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Abstract

Background: Previous findings support the claim intensive care unit (ICU) patients have a higher rate of comorbidities and reduction of health- and functional status compared with the normal population.

Aim: In this prospective observational study, our aim was to determine those health-related factors at the age of 31 years which were associated with a later critical illness among previously un-hospitalized individuals by exploring data obtained from the Northern Finland Birth Cohort 1966 (NFBC1966).

Methods: NFBC1966 is a Finnish birth cohort, which includes 12,058 live births with expected dates of delivery during 1966. The study was conducted among cohort participants who had not been hospitalized for any reason before the cohort follow-up visit at the age of 31. The study group included NFBC1966 participants who were admitted to the ICU of the Oulu University Hospital. The control group included participants who were treated for any reason in regular hospital wards. The data considering the participants' health status and behavior at the age of 31 were collected from the NFBC1966 database. The gathering of ICU and hospitalization data was concluded on December 31, 2016.

Results: 849 NFBC1966 participants met the inclusion criteria: 69 were treated in the ICU (study group) and 780 on regular hospital wards (controls). In the study group, the rate of neurological diseases (26% vs. 16%, 95% CI: -21.8%, -0.2%), malignancy (3% vs. 0.7%, 95% CI: -9.7%, 0.0%), alcohol abuse (4.5% vs. 1%, 95% CI: -11.5%, -0.3%) and smoking (77% vs. 65%, 95% CI: -21.6%, -0.3%) were higher compared with the control group. The patients in the ICU group were also more prone to violent injuries, (17% vs. 7%, 95% CI: -20.2%, -1.9%), practiced less hard physical activity (65% vs. 78%, 95% CI: 2.1%, 25.3%) and had lower maximal muscle strength according to the hand grip test (30 vs. 34 kg, 95% CI: -8.2, 8.6 kg).

Conclusions: In this study examining previously un-hospitalized patients, the main factors associated with future critical illness were neurological comorbidities, malignancy, alcohol misuse, smoking, low maximum muscle strength, and less frequent physical exercise compared with those with hospitalization not requiring ICU admission.

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重病前的健康状况和生活质量：芬兰北部出生队列 1966 年研究。

背景：以前的研究结果表明，重症监护病房（ICU）患者与正常人相比，合并症发生率更高，健康状况和功能状态也有所下降：目的：在这项前瞻性观察研究中，我们的目的是通过研究1966年芬兰北部出生队列（NFBC1966）中的数据，确定在31岁时与以前未住院的人后来患危重病有关的健康相关因素：NFBC1966是一个芬兰出生队列，包括12 058名预产期在1966年的活产婴儿。研究对象是在31岁进行队列随访之前未因任何原因住院的队列参与者。研究组包括入住奥卢大学医院重症监护室的 NFBC1966 参与者。对照组包括因任何原因在普通病房接受治疗的参与者。研究人员从 NFBC1966 数据库中收集了参与者 31 岁时的健康状况和行为数据。重症监护室和住院数据的收集工作于2016年12月31日结束：849名NFBC1966参与者符合纳入标准：69人在重症监护室接受治疗（研究组），780人在普通病房接受治疗（对照组）。与对照组相比，研究组中患神经系统疾病（26% 对 16%，95% CI：-21.8%，-0.2%）、恶性肿瘤（3% 对 0.7%，95% CI：-9.7%，0.0%）、酗酒（4.5% 对 1%，95% CI：-11.5%，-0.3%）和吸烟（77% 对 65%，95% CI：-21.6%，-0.3%）的比例更高。重症监护室组患者也更容易受到暴力伤害（17% 对 7%，95% CI：-20.2%，-1.9%），较少进行剧烈运动（65% 对 78%，95% CI：2.1%，25.3%），手部握力测试显示的最大肌力较低（30 kg 对 34 kg，95% CI：-8.2，8.6 kg）：在这项针对既往未住院患者的研究中，与不需要入住重症监护室的住院患者相比，与未来危重病相关的主要因素包括神经系统合并症、恶性肿瘤、酗酒、吸烟、最大肌力较低以及较少进行体育锻炼。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Anaesthesiologica Scandinavica 医学-麻醉学

CiteScore

4.30

自引率

9.50%

发文量

157

审稿时长

3-8 weeks

期刊介绍： Acta Anaesthesiologica Scandinavica publishes papers on original work in the fields of anaesthesiology, intensive care, pain, emergency medicine, and subjects related to their basic sciences, on condition that they are contributed exclusively to this Journal. Case reports and short communications may be considered for publication if of particular interest; also letters to the Editor, especially if related to already published material. The editorial board is free to discuss the publication of reviews on current topics, the choice of which, however, is the prerogative of the board. Every effort will be made by the Editors and selected experts to expedite a critical review of manuscripts in order to ensure rapid publication of papers of a high scientific standard.