Prediction of Bone Remodeling in Rat Caudal Vertebrae Based on Fluid-Solid Coupling Simulation

IF 3 2区 医学 Q3 ENGINEERING, BIOMEDICAL Annals of Biomedical Engineering Pub Date : 2024-06-28 DOI:10.1007/s10439-024-03562-5
Sen Zhao, Yan Gao, Huijie Leng, Lianwen Sun, Bo Huo
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Abstract

Some previous researches have demonstrated that appropriate mechanical stimulation can enhance bone formation. However, most studies have employed the strain energy density (SED) method for predicting bone remodeling, with only a few considering the potential impact of wall fluid shear stress (FSS) on this process. To bridge this gap, the current study compared the prediction of bone formation and resorption via SED and wall FSS by using fluid-solid coupling numerical simulation. Specifically, 8-week-old female Sprague–Dawley rats were subjected to stretching of the eighth caudal vertebra using a custom-made device. Based on micro-computed tomography images, a three-dimensional model integrating fluid–solid coupling was created to represent compact bone, cancellous bone, and bone marrow. The animals were grouped into control, 1 Hz, and 10 Hz categories, wherein a tensile displacement load of 1000 με was applied to the loading end. The results revealed that SED values tended to increase with elevated porosity, whereas wall FSS values decreased it. Notably, wall FSS demonstrated the higher predictive accuracy for cancellous bone resorption than SED. These findings support the notion that fluid flow within cancellous bone spaces can significantly impact bone resorption. Therefore, the findings of this study contribute to a more comprehensive understanding of the role of wall FSS in bone remodeling, providing a theoretical support for the dynamic evolution of bone structures under mechanical stimulation.

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基于流固耦合模拟的大鼠尾椎骨重塑预测
之前的一些研究表明,适当的机械刺激可以促进骨形成。然而,大多数研究都采用应变能密度(SED)方法预测骨重塑,只有少数研究考虑了壁流体剪应力(FSS)对这一过程的潜在影响。为了弥补这一差距,本研究通过流固耦合数值模拟,比较了通过 SED 和壁面 FSS 预测骨形成和骨吸收的情况。具体来说,使用定制装置对 8 周大的雌性 Sprague-Dawley 大鼠的第八节尾椎进行拉伸。根据微型计算机断层扫描图像,创建了一个集成流固耦合的三维模型,以表示密实骨、松质骨和骨髓。将动物分为对照组、1 Hz 组和 10 Hz 组,在加载端施加 1000 με 的拉伸位移载荷。结果表明,随着孔隙率的增加,SED 值呈上升趋势,而壁面 FSS 值则呈下降趋势。值得注意的是,与 SED 相比,壁面 FSS 对松质骨吸收的预测准确性更高。这些发现支持了这样一种观点,即松质骨空间内的流体流动会对骨吸收产生重大影响。因此,本研究的发现有助于更全面地了解壁面 FSS 在骨重塑中的作用,为机械刺激下骨结构的动态演变提供了理论支持。
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来源期刊
Annals of Biomedical Engineering
Annals of Biomedical Engineering 工程技术-工程:生物医学
CiteScore
7.50
自引率
15.80%
发文量
212
审稿时长
3 months
期刊介绍: Annals of Biomedical Engineering is an official journal of the Biomedical Engineering Society, publishing original articles in the major fields of bioengineering and biomedical engineering. The Annals is an interdisciplinary and international journal with the aim to highlight integrated approaches to the solutions of biological and biomedical problems.
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