Neuroimmune Interactions in the Intestine.

IF 26.9 1区 医学 Q1 IMMUNOLOGY Annual review of immunology Pub Date : 2024-06-01 DOI:10.1146/annurev-immunol-101921-042929
Antonia Wallrapp, Isaac M Chiu
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Abstract

Recent advances have contributed to a mechanistic understanding of neuroimmune interactions in the intestine and revealed an essential role of this cross talk for gut homeostasis and modulation of inflammatory and infectious intestinal diseases. In this review, we describe the innervation of the intestine by intrinsic and extrinsic neurons and then focus on the bidirectional communication between neurons and immune cells. First, we highlight the contribution of neuronal subtypes to the development of colitis and discuss the different immune and epithelial cell types that are regulated by neurons via the release of neuropeptides and neurotransmitters. Next, we review the role of intestinal inflammation in the development of visceral hypersensitivity and summarize how inflammatory mediators induce peripheral and central sensitization of gut-innervating sensory neurons. Finally, we outline the importance of immune cells and gut microbiota for the survival and function of different neuronal populations at homeostasis and during bacterial and helminth infection.

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肠道中的神经免疫相互作用
最近的研究进展有助于从机理上理解肠道中的神经免疫相互作用,并揭示了这种交叉对话在肠道稳态以及调节炎症性和传染性肠道疾病方面的重要作用。在这篇综述中,我们将描述肠道内在和外在神经元的神经支配,然后重点讨论神经元和免疫细胞之间的双向交流。首先,我们强调神经元亚型对结肠炎发展的贡献,并讨论神经元通过释放神经肽和神经递质调节的不同免疫细胞和上皮细胞类型。接下来,我们回顾了肠道炎症在内脏超敏反应发展中的作用,并总结了炎症介质如何诱导肠道支配感觉神经元的外周和中枢敏化。最后,我们概述了免疫细胞和肠道微生物群对不同神经元群在平衡状态下以及细菌和蠕虫感染期间的生存和功能的重要性。
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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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