Computed tomography angiography and coronary artery disease-reporting and data system and a 5-year prognostic major adverse cardiovascular and cerebral event outcome study in a symptomatic Southeast Asian population.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Coronary artery disease Pub Date : 2024-12-01 Epub Date: 2024-07-01 DOI:10.1097/MCA.0000000000001403

Kan Witoonchart, Witoonchart Wannit, Chintanavilas Kumpol

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Abstract

Background: This study investigated the relationship between coronary artery disease-reporting and data system (CAD-RADS) for coronary computed tomography angiogram (CCTA) and major adverse cardiovascular and cerebral event (MACE) in a symptomatic Southeast Asian, Thai population over a 5-year period.

Methods: A retrospective cohort study of Thai patients without known CAD who underwent CCTA for CAD symptoms. CCTA images and 5-year health data were reviewed for CAD-RADS and MACE. MACE consists of all-cause mortality, cardiovascular death, acute coronary syndrome, heart failure hospitalization, and stroke.

Results: In total 336 patients were evaluated. The median follow-up period was 6.4 years. The overall MACE incidence was 63 cases (18.8%). The MACE event rate was progressively increased with higher CAD-RADS categories; CAD-RADS 3 [hazard ratio (HR), 3.62; P = 0.015], CAD-RADS 4a (HR, 3.50; P = 0.024), CAD-RADS 4b & 5 (HR, 7.56; P = 0.001). The risk of MACE increased significantly in the moderate to severe CAD burden group (HR, 5.58; P = 0.01). Kaplan-Meier curve showed a significant rise in MACE with higher CAD-RADS categories ( P = 0.01).

Conclusion: CAD-RADS classification has a significant prognostic value in Southeast Asian, Thai population with cardiac symptoms.

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计算机断层扫描血管造影和冠状动脉疾病报告和数据系统，以及在有症状的东南亚人群中进行的一项为期 5 年的预后主要不良心血管和脑事件结果研究。

研究背景本研究调查了东南亚泰国无症状人群在 5 年内冠状动脉计算机断层扫描血管造影（CCTA）的冠状动脉疾病报告和数据系统（CAD-RADS）与主要不良心脑血管事件（MACE）之间的关系：方法：一项回顾性队列研究，研究对象是因出现 CAD 症状而接受 CCTA 检查的无已知 CAD 的泰国患者。对 CCTA 图像和 5 年的健康数据进行了 CAD-RADS 和 MACE 检查。MACE包括全因死亡、心血管死亡、急性冠状动脉综合征、心衰住院和中风：共对 336 名患者进行了评估。中位随访时间为 6.4 年。总体MACE发生率为63例（18.8%）。MACE发生率随着CAD-RADS分类的升高而逐渐升高：CAD-RADS 3 [危险比（HR），3.62；P = 0.015]，CAD-RADS 4a (HR，3.50；P = 0.024)，CAD-RADS 4b & 5 (HR，7.56；P = 0.001)。中度至重度 CAD 负担组的 MACE 风险明显增加（HR，5.58；P = 0.01）。Kaplan-Meier曲线显示，CAD-RADS分级越高，MACE风险越显著上升（P = 0.01）：结论：CAD-RADS 分级对有心脏症状的东南亚泰国人群具有重要的预后价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Coronary artery disease 医学-外周血管病

CiteScore

2.50

自引率

0.00%

发文量

190

审稿时长

6-12 weeks

期刊介绍： Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management. Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.