The pleiotropic CLEC10A: implications for harnessing this receptor in the tumor microenvironment.

IF 4.6 2区医学 Q1 PHARMACOLOGY & PHARMACY Expert Opinion on Therapeutic Targets Pub Date : 2024-07-01 Epub Date: 2024-07-03 DOI:10.1080/14728222.2024.2374743

Nadia L van der Meijs, Maria Alejandra Travecedo, Filipa Marcelo, Sandra J van Vliet

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Abstract

Introduction: CLEC10A is a C-type lectin receptor that specifically marks the conventional dendritic cell subsets two and three (cDC2 and DC3). It has a unique recognition profile of glycan antigens, with terminal N-Acetylgalactosamine residues that are frequently present in the tumor microenvironment. Even though CLEC10A expression allows for precise targeting of cDC2 and DC3 for the treatment of cancer, CLEC10A signaling has also been associated with anti-inflammatory responses that would promote tumor growth.

Areas covered: Here, we review the potential benefits and drawbacks of CLEC10A engagement in the tumor microenvironment. We discuss the CLEC10A-mediated effects in different cell types and incorporate the pleiotropic effects of IL-10, the main anti-inflammatory response upon CLEC10A binding.

Expert opinion: To translate this to a successful CLEC10A-mediated immunotherapy with limited tumor-promoting capacities, finding the right ligand presentation and adjuvant combination will be key.

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多效应 CLEC10A：在肿瘤微环境中利用这种受体的意义。

简介CLEC10A 是一种 C 型凝集素受体，可特异性标记传统树突状细胞亚群二和三（cDC2 和 DC3）。它对糖类抗原具有独特的识别特征，其末端的 N-乙酰半乳糖胺残基经常出现在肿瘤微环境中。尽管 CLEC10A 的表达允许精确靶向 cDC2 和 DC3 治疗癌症，但 CLEC10A 信号也与促进肿瘤生长的抗炎反应有关：在此，我们回顾了 CLEC10A 参与肿瘤微环境的潜在益处和弊端。我们讨论了CLEC10A在不同细胞类型中介导的效应，并结合了IL-10的多效应，IL-10是CLEC10A结合后的主要抗炎反应：专家观点：要将其成功转化为CLEC10A介导的、具有有限肿瘤促进能力的免疫疗法，关键在于找到正确的配体表达方式和辅助疗法组合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Opinion on Therapeutic Targets 医学-药学

CiteScore

8.90

自引率

1.70%

发文量

审稿时长

3 months

期刊介绍： The journal evaluates molecules, signalling pathways, receptors and other therapeutic targets and their potential as candidates for drug development. Articles in this journal focus on the molecular level and early preclinical studies. Articles should not include clinical information including specific drugs and clinical trials. The Editors welcome: Reviews covering novel disease targets at the molecular level and information on early preclinical studies and their implications for future drug development. Articles should not include clinical information including specific drugs and clinical trials. Original research papers reporting results of target selection and validation studies and basic mechanism of action studies for investigative and marketed drugs. The audience consists of scientists, managers and decision makers in the pharmaceutical industry, academic researchers working in the field of molecular medicine and others closely involved in R&D.