Biosensors with left ventricular assist devices.

IF 4.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Heart Failure Reviews Pub Date : 2024-09-01 Epub Date: 2024-06-28 DOI:10.1007/s10741-024-10413-x
Mahmoud Abbassy, Muhammad Zain Ali, Riya Manas Sharma, Yohan Porus Irani, Adil Dahlan, Maimoona Azhar, Nadeem Aslam, Babar Hasan, Aamir Hameed
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Abstract

Heart failure imposes a significant global health burden, standing as a primary contributor to mortality. Various indicators and physiological shifts within the body may hint at distinct cardiac conditions. Specific biosensors have the capability to identify these changes. Integrating or embedding these biosensors into mechanical circulatory support devices (MCSDs), such as left ventricular assist devices (LVADs), becomes crucial for monitoring alterations in biochemical and physiological factors subsequent to an MCSD implantation. Detecting abnormal changes early in the course of disease progression will allow for improved patient outcomes and prognosis following an MCSD implantation. The aim of this review is to explore the available biosensors that may be coupled or implanted alongside LVADs to monitor biomarkers and changes in physiological parameters. Different fabrication materials for the biosensors are discussed, including their advantages and disadvantages. This review also examines the feasibility of integrating feedback control mechanisms into LVAD systems using data from the biosensors. Challenges facing this emerging technology and future directions for research and development are outlined as well. The overarching goal is to provide an overview of how implanted biosensors may improve the performance and outcomes of LVADs through continuous monitoring and closed-loop control.

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带有左心室辅助装置的生物传感器。
心力衰竭给全球健康带来沉重负担,是导致死亡的主要因素。人体内的各种指标和生理变化可能暗示着不同的心脏状况。特定的生物传感器能够识别这些变化。将这些生物传感器集成或嵌入机械循环支持装置(MCSD),如左心室辅助装置(LVAD),对于监测 MCSD 植入后生化和生理因素的变化至关重要。在疾病进展的早期发现异常变化将有助于改善植入 MCSD 后患者的预后。本综述旨在探讨现有的生物传感器,这些传感器可与 LVAD 相结合或植入 LVAD,以监测生物标志物和生理参数的变化。文中讨论了生物传感器的不同制造材料,包括其优缺点。本综述还探讨了利用生物传感器的数据将反馈控制机制整合到 LVAD 系统中的可行性。此外,还概述了这一新兴技术所面临的挑战以及未来的研发方向。总体目标是概述植入式生物传感器如何通过持续监测和闭环控制改善 LVAD 的性能和效果。
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来源期刊
Heart Failure Reviews
Heart Failure Reviews 医学-心血管系统
CiteScore
10.40
自引率
2.20%
发文量
90
审稿时长
6-12 weeks
期刊介绍: Heart Failure Reviews is an international journal which develops links between basic scientists and clinical investigators, creating a unique, interdisciplinary dialogue focused on heart failure, its pathogenesis and treatment. The journal accordingly publishes papers in both basic and clinical research fields. Topics covered include clinical and surgical approaches to therapy, basic pharmacology, biochemistry, molecular biology, pathology, and electrophysiology. The reviews are comprehensive, expanding the reader''s knowledge base and awareness of current research and new findings in this rapidly growing field of cardiovascular medicine. All reviews are thoroughly peer-reviewed before publication.
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