Porcine-derived Acellular Dermal Matrix for Temporary Soft Tissue Coverage in Locally Advanced Angiosarcoma of the Face - A Soft Tissue Odyssey?

IF 1.8 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL In vivo Pub Date : 2024-07-01 DOI:10.21873/invivo.13646
Marcel Ebeling, Andreas Sakkas, Spyridoula Derka, Mario Scheurer, Alexander Schramm, Frank Wilde, Sebastian Pietzka
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Abstract

Background/aim: Angiosarcomas of the face are rare but present significant treatment challenges due to their origin in the supportive tissues of blood or lymphatic vessels. Achieving optimal balance between oncological efficacy and aesthetic outcomes requires a multidisciplinary approach, particularly in cases where radical R0 resection is necessary. Delays often occur, especially during histopathological examinations, which can complicate primary plastic reconstruction before definitive pathological findings.

Case report: To address this issue, we present a case with the use of porcine-derived acellular dermal matrix for temporary soft tissue coverage as a viable option in a case of angiosarcoma of the face. This is particularly useful in situations where frozen sections risk the loss of critical anatomical structures and intraoperative diagnosis is not feasible. This approach allowed for satisfactory wound coverage and granulation during diagnostic phases, paving the way for oncologically manageable situations and functional rehabilitation.

Conclusion: Temporary soft tissue coverage with porcine-derived acellular dermal matrix is a valuable option in tumor surgery of rare and complex situations.

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用于局部晚期面部血管肉瘤临时软组织覆盖的玻尿酸衍生细胞真皮基质--软组织奥德赛?
背景/目的:面部血管肉瘤非常罕见,但由于其起源于血液或淋巴管的支持组织,给治疗带来了巨大挑战。要在肿瘤疗效和美学效果之间取得最佳平衡,需要采用多学科方法,尤其是在必须进行根治性 R0 切除的病例中。延误经常发生,尤其是在组织病理学检查期间,这可能会在明确的病理结果出来之前使初级整形重建复杂化:为了解决这个问题,我们介绍了一个病例,在面部血管肉瘤的病例中,我们采用了源自猪皮的非细胞真皮基质进行临时软组织覆盖,这是一种可行的选择。在冷冻切片有可能丢失关键解剖结构且无法进行术中诊断的情况下,这种方法尤其有用。这种方法可在诊断阶段获得满意的伤口覆盖和肉芽组织,为肿瘤学可控情况和功能康复铺平道路:结论:在罕见和复杂的肿瘤手术中,使用孔源性非细胞真皮基质进行临时软组织覆盖是一种有价值的选择。
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来源期刊
In vivo
In vivo 医学-医学:研究与实验
CiteScore
4.20
自引率
4.30%
发文量
330
审稿时长
3-8 weeks
期刊介绍: IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.
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