A comprehensive review of the typical and atypical side effects of gabapentin.

IF 2.5 3区 医学 Q2 ANESTHESIOLOGY Pain Practice Pub Date : 2024-11-01 Epub Date: 2024-07-01 DOI:10.1111/papr.13400
Angela Nwankwo, Dhanalakshmi Koyyalagunta, Billy Huh, Ryan Steven D'Souza, Saba Javed
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Abstract

Background: Gabapentin, a widely prescribed medication for various neuropathic pain conditions, has demonstrated efficacy in managing diverse neurological disorders. While conventional side effects are well-documented, a growing body of evidence suggests the existence of atypical side effects, necessitating comprehensive exploration. This paper aims to systematically review and summarize the literature on the atypical side effects of gabapentin, shedding light on manifestations beyond the conventional spectrum.

Methods: A systematic review was conducted, encompassing peer-reviewed articles published up to the knowledge cutoff date in November 2023. Databases, specifically PubMed, were searched for relevant studies, focusing on atypical side effects such as myoclonus, ataxia, pediatric aggression, respiratory depression, pneumonia, pregnancy complications, sleep interference, encephalopathy, peripheral edema, suicidal ideation, dyskinesia, anorgasmia, and myopathy. Inclusion criteria comprised studies with a focus on gabapentin-related atypical side effects, published in recognized journals and involving human subjects.

Results: The review identified a spectrum of atypical side effects associated with gabapentin use, ranging from neurological manifestations like myoclonus and ataxia to behavioral changes such as pediatric aggression and suicidal ideation. Additionally, respiratory complications, pregnancy-related issues, sleep disturbances, and rare complications like encephalopathy and myopathy were observed. Literature synthesis provided insights into the incidence, clinical presentation, and potential mechanisms underlying these atypical side effects.

Conclusion: This comprehensive review highlights the diverse range of atypical side effects associated with gabapentin use, expanding beyond conventional knowledge. Healthcare practitioners must be cognizant of these manifestations, recognizing their potential impact on patient well-being. As clinical decision-making relies on a thorough understanding of a medication's side effect profile, this review contributes to enhancing awareness and fostering informed practices in the prescription and management of gabapentin. Further research is warranted to elucidate the mechanisms and risk factors associated with these atypical side effects, refining our understanding of gabapentin's safety profile.

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全面回顾加巴喷丁的典型和非典型副作用。
背景:加巴喷丁是一种广泛用于治疗各种神经病理性疼痛的处方药,在治疗各种神经系统疾病方面疗效显著。虽然传统的副作用已得到充分证实,但越来越多的证据表明存在非典型副作用,因此有必要进行全面探讨。本文旨在系统回顾和总结有关加巴喷丁非典型副作用的文献,揭示超出常规范围的表现:本文对截至 2023 年 11 月知识截止日发表的同行评审文章进行了系统回顾。在数据库(尤其是 PubMed)中搜索相关研究,重点关注非典型副作用,如肌阵挛、共济失调、儿科攻击行为、呼吸抑制、肺炎、妊娠并发症、睡眠干扰、脑病、外周水肿、自杀意念、运动障碍、性高潮和肌病。纳入标准包括以加巴喷丁相关的非典型副作用为重点、发表在公认期刊上并涉及人体的研究:综述发现了与使用加巴喷丁相关的一系列非典型副作用,包括肌阵挛和共济失调等神经系统表现,以及儿科攻击行为和自杀意念等行为变化。此外,还观察到呼吸系统并发症、妊娠相关问题、睡眠障碍以及脑病和肌病等罕见并发症。通过文献综述,我们了解了这些非典型副作用的发生率、临床表现和潜在机制:这篇综合性综述强调了与使用加巴喷丁相关的各种非典型副作用,拓展了传统知识。医疗从业人员必须认识到这些表现形式,认识到它们对患者福祉的潜在影响。由于临床决策有赖于对药物副作用的全面了解,因此本综述有助于在处方和管理加巴喷丁时提高人们的认识并促进知情实践。我们有必要开展进一步研究,阐明与这些非典型副作用相关的机制和风险因素,从而进一步了解加巴喷丁的安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pain Practice
Pain Practice ANESTHESIOLOGY-CLINICAL NEUROLOGY
CiteScore
5.60
自引率
3.80%
发文量
92
审稿时长
6-12 weeks
期刊介绍: Pain Practice, the official journal of the World Institute of Pain, publishes international multidisciplinary articles on pain and analgesia that provide its readership with up-to-date research, evaluation methods, and techniques for pain management. Special sections including the Consultant’s Corner, Images in Pain Practice, Case Studies from Mayo, Tutorials, and the Evidence-Based Medicine combine to give pain researchers, pain clinicians and pain fellows in training a systematic approach to continuing education in pain medicine. Prior to publication, all articles and reviews undergo peer review by at least two experts in the field.
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