Association of Specific Leg Muscle Strength and Motor Features in Parkinson's Disease.

IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY Parkinson's Disease Pub Date : 2024-06-20 eCollection Date: 2024-01-01 DOI:10.1155/2024/5580870
Chatkaew Pongmala, Chernkhuan Stonsaovapak, Austin Luker, Alexis Griggs, Miriam van Emde Boas, Jacob M Haus, Nicolaas I Bohnen
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Abstract

Background: Postural instability and gait difficulties (PIGD) are a significant cause of falls, mobility loss, and lower quality of life in Parkinson's disease (PD). The connection between PD progression and diminished strength in the lower limbs has been acknowledged. However, the identification of specific muscle groups linked to PIGD and non-PIGD motor features is still unknown.

Objective: To explore the relationship between the strength of specific lower limb muscle groups, along with muscle mass, and their associations with PIGD, PIGD subtypes, and non-PIGD motor features in PD.

Methods: 95 PD participants underwent detailed motor and non-motor test batteries, including lower limb isometric strength testing and whole-body lean mass assessments. Correlation analysis and univariate and multivariate linear/logistic forward stepwise regression were performed to test associations between PIGD and non-PIGD motor features with normalized value (z-score) of lower limb muscle strength and measures of lean mass.

Results: Multivariate regression analysis, adjusted for age, gender, and levodopa equivalent dose, revealed that hip abductor strength was significantly associated with overall PIGD motor severity ratings (p < 0.001), impaired balance (p < 0.001), and non-PIGD Parkinsonian motor features (p < 0.001). Conversely, hip extensor strength was significantly associated with falls, slow walking, and FoG motor features (p=0.016; p=0.003; p=0.020, respectively).

Conclusion: We found that lower hip abductor strength was associated with PIGD and non-PIGD motor features. The association between non-PIGD motor features may suggest specific vulnerability of the hip abductors as part of a proposed brain-muscle loop hypothesis in PD. Moreover, lower hip extensor strength correlated with falls, slow walking, and FoG.

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帕金森病患者腿部特定肌肉力量与运动特征的关系
背景:姿势不稳和步态困难(PIGD)是帕金森病(PD)患者跌倒、行动不便和生活质量下降的重要原因。帕金森病的进展与下肢力量减弱之间的联系已得到公认。然而,与帕金森病和非帕金森病运动特征相关的特定肌肉群的识别仍是未知数:探索特定下肢肌群的力量与肌肉质量之间的关系,以及它们与 PIGD、PIGD 亚型和非 PIGD 运动特征之间的关联。方法:95 名 PD 患者接受了详细的运动和非运动测试,包括下肢等长力量测试和全身瘦体重评估。进行了相关性分析、单变量和多变量线性/逻辑前向逐步回归,以检验 PIGD 和非 PIGD 运动特征与下肢肌力归一化值(z-score)和瘦体重测量值之间的关联:经年龄、性别和左旋多巴当量剂量调整后的多变量回归分析表明,髋关节外展肌力与帕金森病运动严重程度总体评分(p < 0.001)、平衡受损(p < 0.001)和非帕金森病运动特征(p < 0.001)显著相关。相反,髋关节外展力量与跌倒、行走缓慢和 FoG 运动特征显著相关(分别为 p=0.016;p=0.003;p=0.020):我们发现,较低的髋外展力量与 PIGD 和非 PIGD 运动特征相关。非 PIGD 运动特征之间的关联可能表明,髋关节外展肌具有特定的脆弱性,这也是所提出的 PD 脑-肌肉环路假说的一部分。此外,较低的髋关节外展肌力与跌倒、慢走和FoG相关。
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来源期刊
Parkinson's Disease
Parkinson's Disease CLINICAL NEUROLOGY-
CiteScore
5.80
自引率
3.10%
发文量
0
审稿时长
18 weeks
期刊介绍: Parkinson’s Disease is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the epidemiology, etiology, pathogenesis, genetics, cellular, molecular and neurophysiology, as well as the diagnosis and treatment of Parkinson’s disease.
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