Malondialdehyde and Zinc May Relate to Severity of Microvascular Complications in Diabetes: A Preliminary Study on Older Adults with Type 2 Diabetes Mellitus in Northeast China.

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY Clinical Interventions in Aging Pub Date : 2024-06-26 eCollection Date: 2024-01-01 DOI:10.2147/CIA.S464615

Min Sun, Guanchi Yan, Siming Sun, Xiaonan Li, Wei Sun, Yuehui Wang

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Abstract

Background: Serum trace elements and oxidative stress factors are related to diabetic microvascular complications. The study was to investigate the complex relationship between trace elements, oxidative stress factors, and the severity of microvascular complications of diabetes in older adults.

Methods: The present study included patients with or without type 2 diabetes, and blood glucose, blood lipids, trace elements (iron, magnesium, zinc), oxidative stress factors (malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC)) were evaluated. Risk factors for the severity of diabetic microvascular complications in older adults with diabetes were also estimated.

Results: There were statistically significant differences in fasting blood glucose (FBG), triglycerides (TG), low density lipoprotein (LDL), glycated hemoglobin (HbAlc), MDA, NO, SOD, T-AOC, magnesium, and zinc between the two groups (P<0.05). Iron (r_Zinc = 0.147, r_SOD = 0.180, r_T-AOC = 0.193, P < 0.05) was positively correlated with zinc, SOD and T-AOC. Iron was negatively correlated with MDA (r_MDA = -0.146, P < 0.05). Magnesium was positively correlated with SOD (r_Magnesium = 0.147, P < 0.05). Zinc (r_SOD = 0.616, r_T-AOC = 0.575, P < 0.01) was positively correlated with SOD and T-AOC. Zinc (r_MDA =-0.636, r_NO=-0.616, P<0.01) was positively correlated with MDA and negatively correlated with NO. The course of disease (18.653, [5.726; 60.764], P <0.01), FBG (1.265, [1.059; 1.511], P <0.05), HbAlc (1.545, [1.431; 1.680], P <0.01), MDA (2.989, [1.900; 4.702], P <0.01) were risk factor for the severity of diabetic microvascular complications. Zinc (0.680, [0.503; 0.919], P < 0.05) and SOD (0.820, [0.698; 0.964], P < 0.05) were protective factors for the severity of diabetic microvascular complications.

Conclusion: Serum trace elements are related to oxidative stress levels in older adults with type 2 diabetes. The more stable trace element in older adults with diabetes, the lower the oxidative stress and the fewer microvascular complications of diabetes.

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丙二醛和锌可能与糖尿病微血管并发症的严重程度有关：中国东北地区老年 2 型糖尿病患者的初步研究》。

背景：血清微量元素和氧化应激因子与糖尿病微血管并发症有关：血清微量元素和氧化应激因子与糖尿病微血管并发症有关。本研究旨在探讨微量元素、氧化应激因子与老年人糖尿病微血管并发症严重程度之间的复杂关系：本研究纳入了患有或未患有 2 型糖尿病的患者，并对其血糖、血脂、微量元素（铁、镁、锌）、氧化应激因子（丙二醛（MDA）、一氧化氮（NO）、超氧化物歧化酶（SOD）和总抗氧化能力（T-AOC））进行了评估。此外，还估算了老年人糖尿病微血管并发症严重程度的风险因素：两组间空腹血糖（FBG）、甘油三酯（TG）、低密度脂蛋白（LDL）、糖化血红蛋白（HbAlc）、MDA、NO、SOD、T-AOC、镁和锌的差异有统计学意义（P）。铁（rZinc = 0.147，rSOD = 0.180，rT-AOC = 0.193，P < 0.05）与锌、SOD 和 T-AOC 呈正相关。铁与 MDA 呈负相关（rMDA = -0.146，P < 0.05）。镁与 SOD 呈正相关（rMagnesium = 0.147，P < 0.05）。锌（rSOD = 0.616，rT-AOC = 0.575，P < 0.01）与 SOD 和 T-AOC 呈正相关。锌（rMDA=-0.636，rNO=-0.616，P）与 MDA 呈正相关，与 NO 呈负相关。病程（18.653，[5.726; 60.764]，P）、FBG（1.265，[1.059; 1.511]，P）、HbAlc（1.545，[1.431; 1.680]，P）是糖尿病微血管并发症严重程度的危险因素。锌（0.680，[0.503；0.919]，P <0.05）和 SOD（0.820，[0.698；0.964]，P <0.05）是糖尿病微血管并发症严重程度的保护因素：结论：血清微量元素与2型糖尿病老年人的氧化应激水平有关。结论：老年 2 型糖尿病患者血清中的微量元素与氧化应激水平有关，微量元素越稳定，氧化应激越低，糖尿病微血管并发症越少。

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.80

自引率

2.80%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.