Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer's Disease: A Review.

IF 2.5 3区 工程技术 Q2 BIOLOGY Yale Journal of Biology and Medicine Pub Date : 2024-06-28 eCollection Date: 2024-06-01 DOI:10.59249/JNKB9714
Jia Yee Lee, Chiew Yen Wong, Rhun Yian Koh, Chooi Ling Lim, Yih Yih Kok, Soi Moi Chye
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Abstract

Neuroinflammation, toxic protein aggregation, oxidative stress, and mitochondrial dysfunction are key pathways in neurodegenerative diseases like Alzheimer's disease (AD). Targeting these mechanisms with antioxidants, anti-inflammatory compounds, and inhibitors of Aβ formation and aggregation is crucial for treatment. Marine algae are rich sources of bioactive compounds, including carbohydrates, phenolics, fatty acids, phycobiliproteins, carotenoids, fatty acids, and vitamins. In recent years, they have attracted interest from the pharmaceutical and nutraceutical industries due to their exceptional biological activities, which include anti-inflammation, antioxidant, anticancer, and anti-apoptosis properties. Multiple lines of evidence have unveiled the potential neuroprotective effects of these multifunctional algal compounds for application in treating and managing AD. This article will provide insight into the molecular mechanisms underlying the neuroprotective effects of bioactive compounds derived from algae based on in vitro and in vivo models of neuroinflammation and AD. We will also discuss their potential as disease-modifying and symptomatic treatment strategies for AD.

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从大型藻类和微型藻类中提取天然生物活性化合物用于治疗阿尔茨海默氏症:综述。
神经炎症、毒性蛋白聚集、氧化应激和线粒体功能障碍是阿尔茨海默病(AD)等神经退行性疾病的关键途径。利用抗氧化剂、抗炎化合物以及 Aβ 形成和聚集抑制剂针对这些机制进行治疗至关重要。海藻是生物活性化合物的丰富来源,包括碳水化合物、酚类、脂肪酸、藻胶蛋白、类胡萝卜素、脂肪酸和维生素。近年来,它们因其特殊的生物活性,包括抗炎、抗氧化、抗癌和抗细胞凋亡等特性,引起了制药和保健品行业的兴趣。多种证据揭示了这些多功能海藻化合物在治疗和控制注意力缺失症方面的潜在神经保护作用。本文将根据神经炎症和注意力缺失症的体外和体内模型,深入探讨从藻类中提取的生物活性化合物具有神经保护作用的分子机制。我们还将讨论它们作为AD疾病调节和对症治疗策略的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Yale Journal of Biology and Medicine
Yale Journal of Biology and Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.00
自引率
0.00%
发文量
41
期刊介绍: The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.
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