Temporal Trends and Burden of Rheumatic Heart Disease in South Asia: A Comprehensive Analysis of Three Decades from Global Burden of Disease Study.

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Global Heart Pub Date : 2024-06-26 eCollection Date: 2024-01-01 DOI:10.5334/gh.1336

Khalid Naseeb, Muhammad Nauman Khan, Najia Aslam Soomro, Abdul Hameed, Gian Chand, Jaghat Ram, Ahmed Raheem

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Abstract

Background: The objective of this study is to conduct a temporal analysis of rheumatic heart disease (RHD) disease burden trends over a 30-year period (1991 to 2021), focusing on prevalence, deaths, and disability-adjusted life years (DALYs) in the South Asia (SA).

Methods: In this ecological study, we analyzed data regarding burden of RHD from the Global Burden of Diseases (GBD) study spanning the years 1991 to 2021 for the SA Region. Estimates of the number RHD-related prevalence, deaths, and DALYs along with age-standardized rates (ASR) per 100,000 population and 95% uncertainty intervals (UI) were evaluated.

Results: The overall prevalent cases of RHD in the 2021 were 54785.1 × 10³ (43328.4 × 10³ to 67605.5 × 10³), out of which 14378.8 × 10³ (11206.9 × 10³ to 18056.9 × 10³) were from SA. The ASR of point prevalence showed upward trend between 1991 and 2021, at global level and for SA with an average annual percentage change (AAPC) of 0.40 (0.39 to 0.40) and 0.12 (0.11 to 0.13), respectively. The overall number of RHD-related deaths in the 2021 were 373.3 × 10³ (324.1 × 10³ to 444.8 × 10³), out of which 215 × 10³ (176.9 × 10³ to 287.8 × 10³) were from SA, representing 57.6% of the global deaths. The ASR of deaths also showed downward trend between 1991 and 2021, at global level and for SA with an AAPC of -2.66 (-2.70 to -2.63) and -2.07 (-2.14 to -2.00), respectively. The ASR of DALYs showed downward trend between 1990 and 2019, at global level and for South Asian region with an AAPC of -2.47 (-2.49 to -2.44) and -2.22 (-2.27 to -2.17), respectively.

Conclusion: The rising age-standardized prevalence of RHD remains a global concern, especially in South Asia which contribute to over 50% of global RHD-related deaths. Encouragingly, declining trends in RHD-related deaths and DALYs hint at progress in RHD management and treatment on both a global and regional scale.

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南亚风湿性心脏病的时间趋势和负担：全球疾病负担研究三十年综合分析》。

背景：本研究旨在对南亚地区风湿性心脏病（RHD）疾病负担趋势进行为期30年（1991年至2021年）的时间分析，重点关注南亚地区的患病率、死亡人数和残疾调整生命年数（DALYs）：在这项生态研究中，我们分析了全球疾病负担（GBD）研究中有关南亚地区 1991 年至 2021 年期间流行性红斑狼疮负担的数据。我们评估了与风湿性关节炎相关的患病人数、死亡人数和残疾调整生命年（DALYs），以及每 10 万人的年龄标准化比率（ASR）和 95% 的不确定性区间（UI）：2021 年流行的脊髓灰质炎病例总数为 54785.1 × 103（43328.4 × 103 至 67605.5 × 103），其中 14378.8 × 103（11206.9 × 103 至 18056.9 × 103）来自南澳大利亚州。1991年至2021年期间，全球和南澳大利亚的点流行率的年平均百分比变化率呈上升趋势，分别为0.40（0.39至0.40）和0.12（0.11至0.13）。2021 年与风疹相关的死亡总人数为 373.3 × 103（324.1 × 103 至 444.8 × 103），其中 215 × 103（176.9 × 103 至 287.8 × 103）来自南澳大利亚，占全球死亡人数的 57.6%。1991 年至 2021 年期间，全球和南澳大利亚的死亡人数的年均增长率也呈下降趋势，年均增长率分别为-2.66（-2.70 至-2.63）和-2.07（-2.14 至-2.00）。1990 年至 2019 年期间，全球和南亚地区的残疾调整寿命年数（ASR）呈下降趋势，AAPC 分别为-2.47（-2.49 至-2.44）和-2.22（-2.27 至-2.17）：按年龄标准化的风湿性心脏病发病率不断上升仍然是全球关注的问题，尤其是在南亚地区，该地区的风湿性心脏病相关死亡人数占全球死亡人数的50%以上。令人鼓舞的是，与风湿性心脏病有关的死亡人数和残疾调整寿命年数呈下降趋势，这表明风湿性心脏病的管理和治疗在全球和地区范围内都取得了进展。

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来源期刊

Global Heart Medicine-Cardiology and Cardiovascular Medicine

CiteScore

5.70

自引率

5.40%

发文量

审稿时长

5 weeks

期刊介绍： Global Heart offers a forum for dialogue and education on research, developments, trends, solutions and public health programs related to the prevention and control of cardiovascular diseases (CVDs) worldwide, with a special focus on low- and middle-income countries (LMICs). Manuscripts should address not only the extent or epidemiology of the problem, but also describe interventions to effectively control and prevent CVDs and the underlying factors. The emphasis should be on approaches applicable in settings with limited resources. Economic evaluations of successful interventions are particularly welcome. We will also consider negative findings if important. While reports of hospital or clinic-based treatments are not excluded, particularly if they have broad implications for cost-effective disease control or prevention, we give priority to papers addressing community-based activities. We encourage submissions on cardiovascular surveillance and health policies, professional education, ethical issues and technological innovations related to prevention. Global Heart is particularly interested in publishing data from updated national or regional demographic health surveys, World Health Organization or Global Burden of Disease data, large clinical disease databases or registries. Systematic reviews or meta-analyses on globally relevant topics are welcome. We will also consider clinical research that has special relevance to LMICs, e.g. using validated instruments to assess health-related quality-of-life in patients from LMICs, innovative diagnostic-therapeutic applications, real-world effectiveness clinical trials, research methods (innovative methodologic papers, with emphasis on low-cost research methods or novel application of methods in low resource settings), and papers pertaining to cardiovascular health promotion and policy (quantitative evaluation of health programs.