Christelle A. Maalouf, Adriana Alberti, Julie Soutourina
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引用次数: 0
Abstract
The Mediator complex is an essential coregulator of RNA polymerase II transcription. More recent developments suggest Mediator functions as a link between transcription regulation, genome organisation and DNA repair mechanisms including nucleotide excision repair, base excision repair, and homologous recombination. Dysfunctions of these processes are frequently associated with human pathologies, and growing evidence shows Mediator involvement in cancers, neurological, metabolic and infectious diseases. The detailed deciphering of molecular mechanisms of Mediator functions, using interdisciplinary approaches in different biological models and considering all functions of this complex, will contribute to our understanding of relevant human diseases.
Mediator 复合物是 RNA 聚合酶 II 转录的重要核心调节因子。最新进展表明，Mediator 在转录调控、基因组组织和 DNA 修复机制（包括核苷酸切除修复、碱基切除修复和同源重组）之间起着纽带作用。这些过程的功能障碍常常与人类病症有关，越来越多的证据表明，Mediator 参与了癌症、神经系统疾病、代谢性疾病和传染性疾病的治疗。在不同的生物模型中采用跨学科方法，并考虑这一复合体的所有功能，详细破译介体功能的分子机制，将有助于我们了解相关的人类疾病。
期刊介绍：
DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses in cells exposed to genomic insult, as well as their relationship to human disease.
DNA Repair publishes full-length research articles, brief reports on research, and reviews. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports also will be considered for publication.
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