Changes in the Treatment and Outcomes of Different Severities of Neonatal Hypoxic Ischemic Encephalopathy in California: A Retrospective Cohort Study.

Research square Pub Date : 2024-06-17 DOI:10.21203/rs.3.rs-4505263/v1

Carolyn Fall, Rebecca Baer, Henry Lee, Christina Chambers, Gretchen Bandoli

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Abstract

Objective: Evaluate the changes in management and outcomes of Californian infants with hypoxic ischemic encephalopathy (HIE).

Study design: Infants with HIE were identified from a California administrative birth cohort using ICD codes and divided into two epochs, Epoch 1 (2010-2015) and Epoch 2 (2016-2019). Risk ratios (RR) for therapeutic hypothermia (TH) in each epoch and their outcomes were calculated using log-linear regression.

Results: In this cohort, 4779 infants with HIE were identified. Incidence of HIE in California increased yearly from 0.5/1,000 California births to a peak of 1.5/1,000 births in 2018. The use of TH in infants with mild HIE increased in Epoch 2 compared to Epoch 1. There was no significant difference in outcomes between epochs for infants with mild HIE that received TH.

Conclusion: Significantly more infants with mild HIE received TH since 2015 in California, but no difference in outcomes was found for these patients.

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加利福尼亚州不同严重程度新生儿缺氧缺血性脑病的治疗和结果变化：回顾性队列研究

研究目的评估加利福尼亚州缺氧缺血性脑病（HIE）婴儿管理和预后的变化：研究设计：使用 ICD 编码从加利福尼亚行政出生队列中识别 HIE 婴儿，并将其分为两个时代：时代 1（2010-2015 年）和时代 2（2016-2019 年）。采用对数线性回归法计算了每个时代治疗性低温（TH）的风险比（RR）及其结果：在该队列中，共发现了 4779 例 HIE 婴儿。加利福尼亚州的 HIE 发病率逐年增加，从 0.5/1,000 例加利福尼亚州新生儿增加到 2018 年的峰值 1.5/1,000 例新生儿。与第一纪元相比，第二纪元对轻度 HIE 婴儿使用 TH 的情况有所增加。不同时期接受TH治疗的轻度HIE婴儿的结果没有明显差异：自2015年以来，加利福尼亚州接受TH治疗的轻度HIE婴儿明显增多，但这些患者的治疗效果没有发现差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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