Estimating the healthcare burden of Prurigo Nodularis in England: a CPRD database study.

Donia Bahloul, Richard Hudson, Orsolya Balogh, Elgan Mathias, Ben Heywood, Ellen Hubbuck, Jules Tavi, Onyi Diribe, Robert McDonald, Simmi Wiggins, Anthony P Bewley
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Abstract

Purpose: Prurigo nodularis (PN) is a skin disease characterized by intensely itchy skin nodules and is associated with a significant healthcare resource utilization (HCRU). This study aimed to estimate the HCRU of patients in England with PN overall and moderate-to-severe PN (MSPN) in particular.

Methods: This retrospective cohort study used data from the Clinical Practice Research Datalink and Hospital Episode Statistics in England. Patients with Mild PN (MiPN) were matched to patients with MSPN by age and gender for the primary analysis. Patients were enrolled in the study between 1st April 2007 and 1st March 2019. All-cause HCRU was calculated, including primary and secondary care contacts and costs (cost-year 2022).

Results: Of 23,522 identified patients, 8,933 met the inclusion criteria, with a primary matched cohort of 2,479 PN patients. During follow up, the matched cohort's primary care visits were 21.27 per patient year (PPY) for MSPN group and 11.35 PPY for MiPN group. Any outpatient visits were 10.72 PPY and 4.87 PPY in MSPN and MiPN groups, respectively. Outpatient dermatology visits were 1.96 PPY and 1.14 PPY in MSPN and MiPN groups, respectively.

Conclusion: PN, especially MSPN, has a high HCRU burden in England, highlighting the need for new and improved disease management treatments.

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估算英格兰结节性瘙痒症的医疗负担:CPRD 数据库研究。
目的:结节性白斑(PN)是一种以皮肤结节剧痒为特征的皮肤病,与医疗资源利用率(HCRU)密切相关。本研究旨在估算英格兰结节性白斑患者的总体医疗资源利用率,尤其是中重度结节性白斑患者的医疗资源利用率:这项回顾性队列研究使用了英格兰临床实践研究数据链(Clinical Practice Research Datalink)和医院病例统计(Hospital Episode Statistics)中的数据。在主要分析中,轻度 PN(MiPN)患者与 MSPN 患者按年龄和性别进行了配对。患者于 2007 年 4 月 1 日至 2019 年 3 月 1 日期间加入研究。研究计算了全因HCRU,包括初级和二级护理接触和成本(2022成本年):在 23522 名已确认的患者中,有 8933 人符合纳入标准,主要匹配队列中有 2479 名 PN 患者。在随访期间,匹配队列中的 MSPN 组患者的初级保健就诊次数为 21.27 次/患者年,MiPN 组患者的初级保健就诊次数为 11.35 次/患者年。MSPN 组和 MiPN 组的门诊就诊率分别为 10.72 人/年和 4.87 人/年。MSPN 组和 MiPN 组的皮肤科门诊费用分别为 1.96PY 和 1.14PY :结论:在英格兰,PN(尤其是 MSPN)造成的 HCRU 负担很高,这凸显了对新的和改进的疾病管理疗法的需求。
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