The relationship between male and female endogenous reproductive hormones levels and subjective cognitive decline score: A cross-sectional analysis of the Pingyin cohort study

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Clinical Endocrinology Pub Date : 2024-07-01 DOI:10.1111/cen.15104

Qi Wang, Ruihong Yu, Chunying Fu, Meiling Li, Xiaoyi Wang, Dongshan Zhu

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Abstract

Objective

Reproductive hormones might impact disease course in cognitive decline. We examined the association between male and female endogenous reproductive hormones and subjective cognitive decline (SCD) score.

Design, Patients and Measurements

A cross-sectional study design was used with baseline data from the Pingyin cohort study, involving 1943 participants aged 45–70 years. Oestrogen (E2), testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured in females and E2 and testosterone were measured in males. We categorised hormones into three levels of low, intermediate and high level. The 9-item subjective cognitive decline questionnaire (SCD-Q9) scores were collected to assess the symptoms of SCD. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence interval (CI) between categorised hormone levels and SCD status. Multivariable linear regression models were also used.

Results

Overall, 1943 participants were involved and 1285 (66.1%) were female. The mean age at baseline was 59.1 (standard deviation 7.1) years. Women with high testosterone levels had a higher probability of having SCD compared with those with low testosterone levels (OR 1.43, 95% CI 1.01–2.05). Men with a high level of testosterone (0.59, 0.35–0.98) and high testosterone/E2 ratio (0.55, 0.33–0.90) were related to decreased chances of having SCD. Each one-unit increase of testosterone was linked to reduced SCD score in males [(β: −.029, 95% CI (−0.052, −0.007)].

Conclusion

There was sex-specific relationship between hormone levels and SCD abnormal. Those with higher testosterone levels in females may increase likelihood of experiencing SCD. Males with higher testosterone levels and higher testosterone/E2 ratio may be associated with reduced likelihood of SCD. The roles of endogenous reproductive hormone levels and their dynamic changes in cognitive function need further investigation.

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男性和女性内源性生殖激素水平与主观认知衰退评分的关系：平阴队列研究的横断面分析。

目的生殖激素可能会影响认知功能衰退的病程。我们研究了男性和女性内源性生殖激素与主观认知功能衰退（SCD）评分之间的关系：研究采用横断面研究设计，基线数据来自平阴队列研究，共有 1943 名 45-70 岁的参与者参与。对女性的雌激素（E2）、睾酮、促卵泡激素（FSH）和促黄体生成素（LH）进行了测量，对男性的雌激素（E2）和睾酮进行了测量。我们将激素分为低、中、高三个水平。我们还收集了 9 项主观认知衰退问卷（SCD-Q9）的得分，以评估 SCD 的症状。多变量逻辑回归模型用于估算激素水平分类与 SCD 状态之间的几率比（ORs）和 95% 的置信区间（CI）。此外还使用了多变量线性回归模型：共有 1943 名参与者，其中 1285 人（66.1%）为女性。基线平均年龄为 59.1 岁（标准偏差为 7.1）。与睾酮水平低的女性相比，睾酮水平高的女性患 SCD 的概率更高（OR 1.43，95% CI 1.01-2.05）。男性睾酮水平高（0.59，0.35-0.98）和睾酮/E2比值高（0.55，0.33-0.90）与患 SCD 的几率降低有关。睾酮每增加一个单位，男性的SCD得分就会降低[（β：-.029，95% CI（-0.052，-0.007）]：结论：激素水平与 SCD 异常之间存在性别特异性关系。女性睾酮水平越高，发生 SCD 的可能性越大。男性睾酮水平越高、睾酮/E2比值越高，发生SCD的可能性就越小。内源性生殖激素水平的作用及其在认知功能中的动态变化需要进一步研究。

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来源期刊

Clinical Endocrinology 医学-内分泌学与代谢

CiteScore

6.40

自引率

3.10%

发文量

192

审稿时长

1 months

期刊介绍： Clinical Endocrinology publishes papers and reviews which focus on the clinical aspects of endocrinology, including the clinical application of molecular endocrinology. It does not publish papers relating directly to diabetes care and clinical management. It features reviews, original papers, commentaries, correspondence and Clinical Questions. Clinical Endocrinology is essential reading not only for those engaged in endocrinological research but also for those involved primarily in clinical practice.