Role of Proinflammatory Cytokines and Genetic Factors Related to Metabolic Alterations in People Living with HIV/AIDS.

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Interferon and Cytokine Research Pub Date : 2024-10-01 Epub Date: 2024-07-01 DOI:10.1089/jir.2024.0052
Cinthia A Molina-Flores, José G Pinales-Rangel, Sandra K Santuario-Facio, Arguiñe I Urraza-Robledo, María E Gutiérrez-Pérez, Alberto A Miranda-Pérez, Francisco C López-Márquez
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Abstract

Metabolic alterations are a common problem in people living with HIV (PLHIV), as a result of a stage of chronic inflammation that affects the homeostasis of the organism. Prolonged exposure to antiretroviral therapy has been associated with developing lipodystrophies that modify lipoprotein metabolism and inflammatory markers such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), which are mediators of the immune response. The study aimed to associate TNF-α and IL-6 levels with their polymorphisms and metabolic alterations in PLIHV. We hypothesized that TNF-α and IL-6 levels and their polymorphisms are associated with metabolic alterations. In total, 185 PLHIV and 51 HIV-negative people were included. Biochemical parameters were determined by colorimetric assay, cytokine levels by immunoassay, and allelic discrimination by quantitative polymerase chain reaction. A correlation was found between TNF-α levels and the variables cholesterol (r = -0.171, P = 0.020) and high-density lipoprotein (HDL) (r = -0.245, P = 0.001). There are associations between HDL levels (P = 0.011) and GG genotype of rs1800629. The results suggest a metabolic alteration related to the constant immune response, especially the production of proinflammatory cytokines such as TNF-α and IL-6. It was observed that genetic factors may influence metabolism alteration, mainly in lipids.

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前炎症细胞因子的作用以及与艾滋病毒/艾滋病感染者代谢改变有关的遗传因素。
代谢改变是艾滋病毒感染者(PLHIV)的常见问题,这是慢性炎症阶段影响机体平衡的结果。长期接受抗逆转录病毒疗法与脂肪变性有关,而脂肪变性会改变脂蛋白代谢和肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)等炎症标志物,它们是免疫反应的介质。本研究旨在将 TNF-α 和 IL-6 水平与 PLIHV 的多态性和代谢改变联系起来。我们假设TNF-α和IL-6水平及其多态性与代谢改变有关。我们共纳入了 185 名 PLHIV 感染者和 51 名 HIV 阴性感染者。生化指标用比色法测定,细胞因子水平用免疫测定法测定,等位基因鉴别用定量聚合酶链反应法测定。结果发现,TNF-α水平与胆固醇(r = -0.171,P = 0.020)和高密度脂蛋白(HDL)(r = -0.245,P = 0.001)变量之间存在相关性。高密度脂蛋白水平(P = 0.011)与 rs1800629 的 GG 基因型有关。结果表明,新陈代谢的改变与持续的免疫反应有关,特别是促炎细胞因子如 TNF-α 和 IL-6 的产生。据观察,遗传因素可能会影响新陈代谢的改变,主要是脂类代谢的改变。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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