Efficacy and Safety of Zolpidem for Musician's Dystonia.

IF 2.5 4区医学 Q2 CLINICAL NEUROLOGY Journal of Movement Disorders Pub Date : 2024-10-01 Epub Date: 2024-07-01 DOI:10.14802/jmd.24121

Shiro Horisawa, Kilsoo Kim, Masato Murakami, Masahiko Nishitani, Takakazu Kawamata, Takaomi Taira

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Abstract

Objective: The efficacy and safety of zolpidem for treating musician's dystonia are not well understood. We aimed to retrospectively investigate the efficacy and safety of zolpidem for treating musician's dystonia.

Methods: We retrospectively reviewed medical records between January 2021 and December 2023 to identify patients with musician's dystonia who had been prescribed zolpidem. Tubiana's Musician's Dystonia Rating Scale (range, 1-5; lower scores indicating greater severity) was used to evaluate musician's dystonia.

Results: Fifteen patients were included in this study. The mean effective dose of zolpidem was 5.3 ± 2.0 mg. The mean effective duration of zolpidem was 4.3 ± 1.2 h. With zolpidem administration, Tubiana's musician's dystonia rating scale score significantly improved from 2.2 ± 1.0 to 4.3 ± 0.8 (48.9% improvement, p < 0.001). Two patients (13.3%) discontinued the drug owing to unsatisfactory results or sleepiness.

Conclusion: The results of this study suggest that zolpidem may be an alternative treatment option for musician's dystonia.

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唑吡坦治疗音乐家肌张力障碍的疗效和安全性。

背景：唑吡坦治疗音乐家肌张力障碍的疗效和安全性尚不清楚：唑吡坦治疗音乐家肌张力障碍的疗效和安全性尚不十分清楚：我们旨在回顾性研究唑吡坦治疗音乐家肌张力障碍的疗效和安全性：我们回顾性审查了 2021 年 1 月至 2023 年 12 月期间的医疗记录，以确定曾被处方唑吡坦的音乐家肌张力障碍患者。采用 Tubiana 音乐家肌张力障碍评级量表（范围为 1-5；分数越低，表示病情越严重）来评估音乐家肌张力障碍：本研究共纳入 15 名患者。唑吡坦的平均有效剂量为 5.3±2.0 毫克。服用唑吡坦后，Tubiana 音乐家肌张力障碍评级量表评分从 2.2±1.0 显著改善至 4.3±0.8 (改善 48.9%, p)：本研究表明，唑吡坦可能是治疗音乐家肌张力障碍的一种替代疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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